Co-Director of the Center:
Michael B. Bracken, Ph.D., M.P.H.
Susan Dwight Bliss Professor of Epidemiology
Professor, Division of Chronic Disease Epidemiology
Phone: (203) 764-9375
Fax: (203) 764-9378
E-mail address: michael.bracken@yale.edu
Professor Bracken's primary research interest is the epidemiology of diseases of pregnancy, newborns and infants, emphasizing environmental and genetic risks for causation and iatrogenic factors in patient care. Professor Bracken is Co-Director of the Yale Center for Perinatal, Pediatric and Environmental Epidemiology, which conducts research in obstetric, perinatal, and neonatal disease. He has received numerous grant awards and published over 300 papers and two books (Perinatal Epidemiology (1984) and Effective Care of the Newborn Infant (with J.C. Sinclair, 1992)). He is an editor of the Cochrane Neonatal Review Group and teaches courses on evidence-based health care and medicine and on pharmaco-epidemiology. Professor Bracken directed the National Acute Spinal Cord Injury randomized trials of therapies to prevent paralysis after injury. In 1990, this group identified the first successful therapy for acute spinal cord injury. A former President of the American College of Epidemiology and President-Elect of the Society for Epidemiologic Research, Professor Bracken is a Fellow of Green College, Oxford University and serves as consultant to national and international governmental agencies and private corporations.
2007 & selected 2006 Publications
Warnick EM, Bracken MB, Kasl SV. Efficiency of the child behavior checklist and strengths and difficulties questionnaire: a systematic review. Child and Adolescent Mental Health, 2007 (in press).
Grosso LM, Triche E, Benowitz NL, Bracken MB. Prenatal caffeine assessment: fetal and maternal biomarkers or self-reported intake? Ann Epidemiol. 2008 Mar;18(3):172-8.
Bracken MB, DeWan A, Hoh J. Genome Wide Association Studies, In Rebbeck TR, Ambrosone CA, Shields, PG. Fundamentals of Molecular Epidemiology. New York: Taylor and Francis, 2007.
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP.Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. BMC Med Genet. 2007 Apr 2; 8:15.
Beckett W, Gent J, Naeher L, Belanger K, Triche E, Bracken MB, Leaderer B. Peak expiratory flow rate variability is not affected by home combustion sources in a group of non-smoking women. Archives of Environmental & Occupational Health, Arch Environ Occup Health. 2006 Jul-Aug;61(4):176-82.
Gould Rothberg BE, Bracken MB . E-cadherin Immunohistochemical Expression as a Prognostic Factor in Infiltrating Ductal Carcinoma of the Breast: a Systematic Review and Meta-Analysis. Breast Cancer Research & Treatment 100(2):139-48, 2006.
Illuzzi JL, Bracken MB . Duration of intrapartum prophylaxis for neonatal group B streptococcal disease: a systematic review. Obstetrics and Gynecology 108: 1254-1265, 2006.
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma. BMC Medical Genetics 7:68, 2006.
Hardy JR, Leaderer BP, Holford TR, Hall GC, Bracken MB. Safety of medications prescribed before and during early pregnancy in a cohort of 81,975 mothers from UK General Practice Research Database. Pharmacoogy and Drug Safey 15:555-564, 2006.
Bracken MB . Cotinine and spontaneous abortion: might variations in metabolism play a role? Epidemiology 17:492-494, 2006.
Bloch MH, Landeros-Weisenberger A, Kelmendi B, Coric V, Bracken MB, Leckman JF. Antipsychotic augmentation with treatment refractory obsessive compulsive disorder: a systematic review. Molecular Psychiatry 7:622-232, 2006.
National Institutes of Health State-of-the Science Conference Statement ( Bracken MB member): Cesarean Delivery on Maternal Request. Obstetrics and Gynecology 107:1386-1397, 2006.
Triche EW, Gent JF, Holford TR, Belanger K, Bracken MB , Beckett WS, McSharry-J-e, Leaderer BP. Low-level ozone exposure and respiratory symptoms in infants. Environmental Health Perspectives 114:911-916, 2006.
Grosso LM, Triche EW, Belanger K, Benowitz NL, Holford TR, Bracken MB. Caffeine metabolites in umbilical cord blood, cytochrome P450 IA2 activity and intra-uterine growth restriction. American Journal of Epidemiology 163: 1035-1041, 2006.
Co-Director of the Center:
Brian P. Leaderer, Ph.D., M.P.H.
Susan Dwight Bliss Professor of Public Heath,
Interim Dean of Public Health,
Interim Chairman, Epidemiology and Public Health,
Division of Environmental Health Sciences
Phone: (203) 785-2867
Fax: (203) 737-6103
E-mail address: brian.leaderer@yale.edu
Dr. Leaderer's research interests are in the area of assessing exposures to air contaminants and assessing the health impact resulting from those exposures in both controlled human and epidemiological studies. His research is interdisciplinary in nature. While typically focusing on indoor air quality issues, its purpose is to establish a close link between exposure assessment and health and comfort effects measured in both chambers and in epidemiologic studies.
Within the context of assessing exposures, his work includes developing a theoretical framework for doing exposure assessment, determining the type and quantity of health related contaminants emitted from sources, assessing environmental concentrations and the factors impacting those concentrations, developing monitoring and modeling techniques and formulating strategies to assess exposures in epidemiologic studies.
Dr. Leaderer is the Principal Investigator on three environmental epidemiologic studies. The first is a prospective study investigating the role of indoor and outdoor air contaminant exposures on daily respiratory symptoms in 918 infants and their nonsmoking mothers. The second is a prospective study of the environmental risk factors in the development of asthma in a population of 1,000 infants followed from birth to age 10. The third study is a prospective study of the role of indoor allergens and air contaminants (indoor and outdoor) on the severity of asthma in 1,000 asthmatic children between the ages of 5 and 11. He is also a co-investigator on several other environmental epidemiologic studies, the Susan Dwight Bliss Professor of Epidemiology, Interim Dean of Public Health and Co-Director of the Yale Center for Perinatal, Pediatric and Environmental Epidemiology.
2007 & selected 2006 Publications
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. BMC Med Genet. 2007 Apr 2; 8:15
Gehring U, Leaderer BP, Heinrich J, Oldenwening M, Giovannangelo ME, Nordling E, Merkel G, Hoek G, Bellander T, Brunekreef B. Comparison of parental reports of smoking and residential air nicotine concentrations in children.
Occup Environ Med. 2006 Nov;63(11):766-72
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma. BMC Med Genet. 2006 Aug 2;7:68
Hardy JR, Leaderer BP, Holford TR, Hall GC, Bracken MB. Safety of medications prescribed before and during early pregnancy in a cohort of 81,975 mothers from the UK General Practice Research Database.
Pharmacoepidemiol Drug Saf. 2006 Aug;15(8):555-64
Triche EW, Gent JF, Holford TR, Belanger K, Bracken MB, Beckett WS, Naeher L, McSharry JE, Leaderer BP. Low-level ozone exposure and respiratory symptoms in infants. Environ Health Perspect. 2006 Jun;114(6):911-6.
Rose D, Mannino DM, Leaderer BP. Asthma prevalence among US adults, 1998-2000: role of Puerto Rican ethnicity and behavioral and geographic factor. Am J Public Health. 2006 May;96(5):880-8. Epub 2006 Mar 29.
Belanger K, Gent JF, Triche EW, Bracken MB, Leaderer BP. Association of indoor nitrogen dioxide exposure with respiratory symptoms in children with asthma. Am J Respir Crit Care Med. 2006 Feb 1;173(3):297-303.
Deputy Director:
Kathleen Belanger, Ph.D.,
Research Scientist
Phone: (203) 764-9375
Fax: (203) 764-9378
E-mail address: kathleen.belanger@yale.edu
Associate Director for Data Analysis and Management:
Elizabeth W. Triche, Ph.D.,
Research Scientist
Phone: (203) 764-9375
Fax: (203) 764-9378
E-mail address: elizabeth.triche@yale.edu
Research Faculty:
Janneane F. Gent, Ph.D.,
Associate Research Scientist
Phone: (203) 764-9375
Fax: (203) 764-9378
E-mail address: janneane.gent@yale.edu
Laura Grosso, Ph.D., Associate Research Scientist
Phone: (203) 764-9375
Fax: (203) 764-9378
E-mail address: laura.grosso@yale.edu
Fellows:
Weily Soong, MD
Phone: (203) 764-9375
Fax: (203) 764-9378
E-mail address: weily.soong@yale.edu
Grace Gong, MD
Phone: (203) 764-9375
Fax: (203) 764-9378
E-mail address: grace.gong@yale.edu
Affiliates:
Helen Kwon, Ph.D., MPH, Kellogg Scholar in Health Disparities
Columbia University School of Public Health, Department of Epidemiology
Phone: 212-304-6424; Fax: 212-305-9413; E-mail address: helen.kwon@columbia.edu
Janet Hardy, Ph.D.
University of Massachusetts Medical School
Department of Medicine
Division of Preventive and Behavioral Medicine
55 Lake Avenue North
Worcester, MA 01655
E-mail address: Janet.Hardy@umassmed.edu
