Human Papillomavirus Vaccine Impact Monitoring Project Across CT (HPV-IMPACT)



This project aims to monitor the impact of human papillomavirus (HPV) vaccine on cervical cancer precursors and HPV types associated with those precursors.   

Goals & Objectives

  • Monitor HPV vaccine impact on cervical cancer precursors, cervical intraepithelial neoplasia (CIN) grade 2 and 3 and adenocarcinoma in situ (AIS).
  • Monitor HPV vaccine impact on HPV types associated with CIN 2/3 and AIS lesions.
  • Improve public health practice through local population-based surveillance of HPV-related cervical cancer precursors.   


Statewide passive monitoring of CIN2/3 and AIS diagnoses from pathology laboratories
Population-based active surveillance for CIN 2/3 and AIS in New Haven county
enhanced data collection to determine HPV vaccination status specimen collection to determine HPV type associated with CIN2/3 and AIS diagnoses.


    1. Linda M. Niccolai, Niti R. Mehta, James L. Hadler. Racial/Ethnic and poverty disparities in human papillomavirus vaccination completion. American Journal of Preventive Medicine. 2011;41(4):428-33.

    2.  DPH.  Human Papillomavirus Types in Connecticut 2008-2009. Connecticut Epidemiologist 2011;31(6):25-26.

    3.  DPH.  The Human Papillomavirus Vaccine Impact Monitoring Project (HPV-IMPACT) - Connecticut, 2008.  Connecticut Epidemiologist  2010;30(2):5-6.

    4.  Susan Hariri, Elizabeth R. Unger, Suzanne E. Powell,  Heidi M. Bauer, Nancy M. Bennett,  Karen C. Bloch , Linda M. Niccolai,  Sean Schafer, Lauri E. Markowitz, The HPV-IMPACT Working Group. The HPV vaccine impact monitoring project (HPV-IMPACT): assessing early evidence of vaccination impact on HPV-associated cervical cancer precursor lesions. Cancer Causes Control. 2011 Nov 23. [Epub ahead of print]

    5. Niccolai LM, Russ C, Julian PJ, Hariri S, Sinard J, Meek JI, McBride V, Markowitz LE, Unger ER, Hadler JL and Sosa LE: Individual and geographic disparities in human papillomavirus types 16/18 in high-grade cervical lesions: Associations with race, ethnicity, and poverty. Cancer. 2013 Aug 15;119 (16) :3052-8. Epub 2013 May 9. PMID: 23661284

    6. Niccolai LM, Julian PJ, Meek JI, McBride V, Hadler JL and Sosa LE: Declining rates of high-grade cervical lesions in young women in Connecticut, 2008-2011. Cancer Epidemiol Biomarkers Prev. 2013 Aug;22 (8) :1446-50. Epub 2013 May 23. PMID: 23704476


Related Links

Connecticut HPV-IMPACT: Summary of Findings, 2008-2014

CT DPH makes CIN2/3 and AIS reportable conditions

 Article about the CT HPV-IMPACT project in the Fall 2011 issue of Yale Public Health:  Tracking HPV.

Project Contact Person
Monica Brackney, MS
Project Coordinator
Connecticut Emerging Infections Program
One Church Street, 7th floor
New Haven, CT 06510
(203) 764-9705