Transmission Dynamics of Enteric Diseases

Professor Pitzer’s research focuses on mathematical modeling of the transmission dynamics of enteric and imperfectly immunizing infections. She studies how interventions such as vaccination, improved treatment of cases, and improvements in sanitation affect disease transmission at the population level. She collaborates with individuals at the US Centers for Disease Control and Prevention (CDC), National Institutes of Health/Fogarty International Center (NIH/FIC), and Oxford University Clinical Research Unit (OUCRU) in Viet Nam, as well as with field researchers in India and Malawi. After receiving her Sc.D. in Epidemiology from Harvard School of Public Health, Dr. Pitzer did her postdoctoral fellowship with Bryan Grenfell at Penn State and Princeton University and the Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Department of Homeland Security and NIH/FIC before coming to Yale School of Public Health.

Projects

Projects

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Rotavirus transmission dynamics and potential impact of vaccination in developing countries

We are using mathematical models to understand patterns of incidence and potential "herd immunity" effects as rotavirus vaccination begins to be rolled out in developing countries.

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vaccine

Understanding variation in rotavirus vaccine efficacy and waning of vaccine-induced immunity

Rotavirus vaccines exhibited considerably lower efficacy during clinical trials conducted in developing countries compared to developed countries. We are using mathematical models to...

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Historical analysis of typhoid fever in US cities

Cities across the United States exhibited different timing in terms of the decline in typhoid mortality during the late 19th and early 20th centuries, and also exhibited very different...

Typhoid conditions

Controlling Endemic Typhoid Fever

We are using mathematical models to evaluate the feasibility and impact of different methods of typhoid control, including vaccination, improved treatment strategies, and investment in...

Publications

Weinberger DM, Warren JL, Steiner CA, Charu V, Viboud C, Pitzer VE: Reduced-Dose Schedule of Prophylaxis Based on Local Data Provides Near-Optimal Protection Against Respiratory Syncytial Virus. Clin Infect Dis. 2015 Apr 22; 2015 Apr 22. PMID: 25904370

Morris SE, Pitzer VE, Viboud C, Metcalf CJ, Bjørnstad ON, Grenfell BT: Demographic buffering: titrating the effects of birth rate and imperfect immunity on epidemic dynamics. J R Soc Interface. 2015 Mar 6. PMID: 25589567

Pitzer VE, Viboud C, Alonso WJ, Wilcox T, Metcalf CJ, Steiner CA, Haynes AK, Grenfell BT: Environmental drivers of the spatiotemporal dynamics of respiratory syncytial virus in the United States. PLoS Pathog. 2015 Jan; 2015 Jan 8. PMID: 25569275

Thompson CN, Kama M, Acharya S, Bera U, Clemens J, Crump JA, Dawainavesi A, Dougan G, Edmunds WJ, Fox K, Jenkins K, Khan MI, Koroivueta J, Levine MM, Martin LB, Nilles E, Pitzer VE, Singh S, Raiwalu RV, Baker S, Mulholland K: Typhoid fever in Fiji: a reversible plague? Trop Med Int Health. 2014 Oct; 2014 Jul 25. PMID: 25066005

Pitzer VE, Bowles CC, Baker S, Kang G, Balaji V, Farrar JJ, Grenfell BT: Predicting the impact of vaccination on the transmission dynamics of typhoid in South Asia: a mathematical modeling study. PLoS Negl Trop Dis. 2014; 2014 Jan 9. PMID: 24416466

Patel MM, Pitzer VE, Alonso WJ, Vera D, Lopman B, Tate J, Viboud C, Parashar UD: Global seasonality of rotavirus disease. Pediatr Infect Dis J. 2013 Apr. PMID: 23190782

Pitzer VE, Burgner D, Viboud C, Simonsen L, Andreasen V, Steiner CA, Lipsitch M: Modelling seasonal variations in the age and incidence of Kawasaki disease to explore possible infectious aetiologies. Proc Biol Sci. 2012 Jul 22; 2012 Mar 7. PMID: 22398170

Pitzer VE, Basta NE: Linking data and models: the importance of statistical analyses to inform models for the transmission dynamics of infections. Epidemiology. 2012 Jul. PMID: 22659545

Atkins KE, Shim E, Pitzer VE, Galvani AP: Impact of rotavirus vaccination on epidemiological dynamics in England and Wales. Vaccine. 2012 Jan 11; 2011 Nov 28. PMID: 22133508

Pitzer VE, Atkins KE, de Blasio BF, Van Effelterre T, Atchison CJ, Harris JP, Shim E, Galvani AP, Edmunds WJ, Viboud C, Patel MM, Grenfell BT, Parashar UD, Lopman BA: Direct and indirect effects of rotavirus vaccination: comparing predictions from transmission dynamic models. PLoS One. 2012; 2012 Aug 13. PMID: 22912699

Lopman BA, Pitzer VE, Sarkar R, Gladstone B, Patel M, Glasser J, Gambhir M, Atchison C, Grenfell BT, Edmunds WJ, Kang G, Parashar UD: Understanding reduced rotavirus vaccine efficacy in low socio-economic settings. PLoS One. 2012; 2012 Aug 6. PMID: 22879893

Pitzer VE, Patel MM, Lopman BA, Viboud C, Parashar UD, Grenfell BT: Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions. Proc Natl Acad Sci U S A. 2011 Nov 29; 2011 Nov 14. PMID: 22084114

Pitzer VE, Viboud C, Lopman BA, Patel MM, Parashar UD, Grenfell BT: Influence of birth rates and transmission rates on the global seasonality of rotavirus incidence. J R Soc Interface. 2011 Nov 7; 2011 Apr 20. PMID: 21508015

Shaman J, Pitzer VE, Viboud C, Grenfell BT, Lipsitch M: Absolute humidity and the seasonal onset of influenza in the continental United States. PLoS Biol. 2010 Feb 23; 2010 Feb 23. PMID: 20186267

Lloyd-Smith JO, George D, Pepin KM, Pitzer VE, Pulliam JR, Dobson AP, Hudson PJ, Grenfell BT: Epidemic dynamics at the human-animal interface. Science. 2009 Dec 4. PMID: 19965751