Transmission Dynamics of Enteric Diseases

Professor Pitzer’s research focuses on mathematical modeling of the transmission dynamics of enteric and imperfectly immunizing infections. She studies how interventions such as vaccination, improved treatment of cases, and improvements in sanitation affect disease transmission at the population level. She collaborates with individuals at the US Centers for Disease Control and Prevention (CDC), National Institutes of Health/Fogarty International Center (NIH/FIC), and Oxford University Clinical Research Unit (OUCRU) in Viet Nam, as well as with field researchers in India and Malawi. After receiving her Sc.D. in Epidemiology from Harvard School of Public Health, Dr. Pitzer did her postdoctoral fellowship with Bryan Grenfell at Penn State and Princeton University and the Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Department of Homeland Security and NIH/FIC before coming to Yale School of Public Health.

Projects

Projects

preview image

Rotavirus transmission dynamics and potential impact of vaccination in developing countries

We are using mathematical models to understand patterns of incidence and potential "herd immunity" effects as rotavirus vaccination begins to be rolled out in developing countries.

vaccine

Understanding variation in rotavirus vaccine efficacy and waning of vaccine-induced immunity

Rotavirus vaccines exhibited considerably lower efficacy during clinical trials conducted in developing countries compared to developed countries. We are using mathematical models to explore potential explanations for this reduced efficacy.

typhoid cartoon crop

Historical analysis of typhoid fever in US cities

Cities across the United States exhibited different timing in terms of the decline in typhoid mortality during the late 19th and early 20th centuries, and also exhibited very different patterns of seasonality that did not follow a clear geographic pattern.

Typhoid conditions

Controlling Endemic Typhoid Fever

We are using mathematical models to evaluate the feasibility and impact of different methods of typhoid control, including vaccination, improved treatment strategies, and investment in clean water and sanitation.