The Aksoy lab studies multiple aspects of tsetse flies, the vectors of African trypanosomes. Trypanosomes are the causative agents of the devastating Sleeping Sickness disease in Sub-Saharan Africa. The lab’s work spans a range of projects including tsetse immunity, reproduction and symbiosis, tsetse-symbiont and trypanosome interactions, tsetse genomics and population genetics, and trypanosome developmental processes in tsetse. The ultimate goal of our work is to improve current control methods and/or develop novel strategies to reduce or eliminate the transmission of Sleeping Sickness in Sub-Saharan Africa.
Victory Over the Vector
- Beadell JS, Hyseni C, Abila PP, Azabo R, Enyaru JC, Ouma JO, Mohammed YO, Okedi LM, Aksoy S, Caccone A: Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. PLoS Negl Trop Dis 2010, 4(3):e636.
- Wang J, Wu Y, Yang G, Aksoy S: Interactions between mutualist Wigglesworthia and tsetse Peptidoglycan Recognition Protein (PGRP-LB) influence trypanosome transmission. Proc Natl Acad Sci USA 2009, in press.
- Weiss BL, Wu Y, Schwank JJ, Tolwinski NS, Aksoy S: An insect symbiosis is influenced by bacterium-specific polymorphisms in outer-membrane protein A. Proc Natl Acad Sci USA 2008, 105(39):15088-15093.
- Attardo GM, Lohs C, Heddi A, Alam UH, Yildirim S, Aksoy S: Analysis of milk gland structure and function in Glossina morsitans: Milk protein production, symbiont populations and fecundity. J Insect Physiol 2008, 54(8):1236-1242.
- Attardo GM, Guz N, Strickler-Dinglasan P, Aksoy S: Molecular aspects of viviparous reproductive biology of the tsetse fly (Glossina morsitans morsitans): Regulation of yolk and milk gland protein synthesis. J Insect Physiol 2006, 52:1128-1136.