Arthur B. DuBois, M.D.
Emeritus Professor,
John Pierce Laboratory
Arthur B. DuBois is an M.D. who has a laboratory in the John B.
Pierce Laboratory at 290 Congress Ave., New Haven, CT 06519. His
teaching appointments at Yale Medical School are as Professor of
Epidemiology and Public Health in the Environmental Health Sciences
Division, and as Professor of Cellular and Molcular Physiology in
the Medical School. Dr. DuBois main field of expertise has been
pulmonary physiology, including environmental effects on the lungs,
In his laboratory, he is currently pursuing two lines of work. The
first is the analysis of nitric oxide gas (NO) in expired air, particulary
air collected as the first part of the expiration and commonly called
the 'dead space.' This region is thought to produce increased amounts
of nitric oxide when inflammed, as in asthma. The second research
project is on the effect of air particles that settle onto a wet
surface in the bronchi or alveoli. The effect under study is the
electromotive force generated when the particles float onto an aqueous
surface, or a surface covered by a thin layer of surface active
material obtained by broncho-alveolar lavage with saline solution.
The question is whether the surface potential generated by the interaction
between the particles and the aqueous surface, about 300 millivolts,
is sufficient to trigger sensitive cells in the airway mucosa to
produce a short-lived eppisode of bronchoconstriction (demonstrated
a number of years ago), or more delayed but longer acting cellular
responses resembling the immune response which the lungs have in
response to an allergenic or infectious agent. The relevance to
public health is that respirable particles cause morbidity and mortality
among a segment of the population in proportion to particle concentration
and to any preexisting pulmonary or cardiac disease.
Selected Publications
DuBois, A.B., Harb, Z.F. and Fox, S.H. Thermal discomfort of respiratory
protective devices. American Industrial Hygiene Associates
Journal 51: 550-554, 1990.
DuBois, A.B., Douglas, J.S., Stitt, J.T. and Mohsenin, V. Production
and absorption of nitric oxide gas in the nose. Journal of
Applied Physiology 84(4): 1217-1244, 1998.
Asgari, M., DuBois, A.B., Asgari, M., Gent, J. and Beckett, W.S.
Association of ambient air quality with children's lung function
in urban and rural Iran. Archives of Environmental Health 53:
222-230, 1998.
Kelly, P.M. and DuBois, A.B. Comparison between the uptake of
nitrous oxide and nitric oxide in the human nose. Journal
of Applied Physiology 85: 1203-1209, 1998.
DuBois, A.B., Kelly, P.M., Douglas, J.S., and Mohsenin, V. Nitric
oxide production in trachea, bronchi, bronchioles, and respiratory
bronchioles of humans. Journal of Applied Physiology 86:
159-167, 1998. |
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