Ralitza Gueorguieva, Ph.D.
Research Scientist,
Biostatistics
Phone: (203) 974-7529
Fax: (203) 785-6912
ralitza.gueorguieva@yale.edu
Professor Gueorguieva's research interests are in methodological development of mixed effects models for analysis of longitudinal and clustered data. One specific area of her research is development of statistical techniques for simultaneous analysis of repeatedly measured categorical and continuous outcomes. She has applied these methods in risk assessment and for simultaneous analysis of measures of disease severity over time.
Professor Gueorguieva is collaborating extensively with psychiatric researchers on clinical trials and observational studies in alcoholism, substance abuse, depression and anxiety disorders, women's behavioral health, schizophrenia, bipolar disorder, obsessive-compulsive disorder and posttraumatic stress disorder. She advocates the use of modern statistical methods such as mixed models and nonparametric alternatives to address the complexity of psychiatric data. Professor Gueorguieva has also been the lead author on studies to develop an improved screening test for very low birth weight and to assess the effect of maternal age on educational disabilities of children.
Curriculum Vitae
Education
Ph.D. in Statistics, University of Florida, 1999
M.Stat. in Statistics with an emphasis in Biostatistics, University of Florida, 1996
M.Sc. in Computer Science, Sofia University, 1994
Awards and Honors
International Biometric Society's Eastern North American Region (ENAR) Student Award, March 1999
The Statistics Faculty Award for the Outstanding Senior Graduate Student, Department of Statistics, University of Florida, 1998
First place, Student Abstract Competition, Annual Florida Epidemiology Meeting, July 1998
R. L. Anderson Student Paper Award, Southern Regional Conference on Statistics, June 1998
International Student Academic Awards, Office of International Studies and Programs, University of Florida, 1996-1998
Professional Services
Associate Editor, Journal of the Royal Statistical Society, Series A,
2007-2010
Member, Editorial Board, Biological Psychiatry, 2007-2010
Chair, Short Course Committee for International Biometrics Conference, Dublin 2008
Publication Officer, Biometrics Section of the American Statistical Association, 2007-2008
Participant in National Institutes of Mental Health Special Emphasis Panel(s), 2004-2007
Current Research Projects
Growth Mixture Modeling of Longitudinal Data; Component Regression; SSRI-induced Changes in Cortical GABA in Women with Premenstrual Dysphoric Disorder (PMDD); Measurement of GABA Synthesis in Depression; Novel Glutamatergic Detoxification Strategies; rTMS Clinical Trial for Auditory Hallucinations; Genetics of Hippocampal Deficits in Bipolar Disorder; Work-Life, Health Habits and Health: Longitudinal Analysis; Symptom-Onset Antidepressant Treatment for PMDD.
Yale Affiliations
Biostatistics Core, Center for the Translational Neuroscience of Alcoholism (CTNA)
In the News
Gueorguieva Author on Study Showing That Medication Eases Obsessive-Compulsive Symptoms
Selected Publications
Gueorguieva, R., Wu, R., Pittman, B., Cramer, J., Rosenheck, R., O’Malley, S., and Krystal, J. New Insights into the Efficacy of Naltrexone Based on Trajectory-Based Reanalyses of Two Negative Clinical Trials. Biological Psychiatry 61: 1290-1295, 2007.
Gueorguieva, R.V. and Sanacora, G. Joint Analysis of Repeatedly Observed Continuous and Ordinal Measures of Disease Severity. Statistics in Medicine 25(8): 1307-1322, 2006.
Gueorguieva, R. Comments about Joint Modeling of Cluster Size and Binary and Continuous Subunit-specific Outcomes. Biometrics 61(3): 862-867, 2005.
Gueorguieva, R.V. and Krystal, J. Move Over ANOVA: Progress in Analyzing Repeated Measures Data and Its Reflection in Papers Published in the Archives of General Psychiatry. Archives of General Psychiatry 61: 310-317, 2004.
Gueorguieva, R.V., Sarkar, N.P., Carter, R.L., Ariet, M., Roth, J., and Resnick, M.B. A Risk Assessment Screening Test for Very Low Birth Weight. Maternal and Child Health Journal 7(2): 127-136, 2003.
Gueorguieva, R.V. and Agresti, A. Correlated Probit Model for Joint Modeling of Clustered Binary and Continuous Response. Journal of the American Statistical Association 96: 1102-1112, 2001.
Gueorguieva, R.V., Carter, R.L., Ariet, M., Roth, J., Mahan, C.S., and Resnick, M.B. Effect of Teenage Pregnancy on Educational Disabilities in Kindergarten. American Journal of Epidemiology 154: 212-220, 2001.
Gueorguieva, R.V. A Multivariate Generalized Linear Mixed Model for Joint Modelling of Clustered Outcomes in the Exponential Family. Statistical Modeling: An International Journal 1: 177-194, 2001.
For a further list of Dr. Gueorguieva's publications, please see Pub Med.
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