Hongyu Zhao, Ph.D.
Professor of Public Health,
Biostatistics
Laboratory Web page
The research interests of the laboratory are to develop mathematical, statistical, and computational methods to address scientific questions raised in molecular biology and genetics. The common theme of projects is to integrate diverse types of genomics, proteomics, and phenotype data at different levels (e.g. cellular, tissue, individual, and population) to dissect biological pathways and networks as well as their responses/interactions with environmental factors. Research topics include: haplotype analysis to investigate the patterns and reasons for genetic differences across populations both within and between different geographical areas; various methods for genetic linkage and association studies to identify genetic variants underlying complex traits; design and analysis issues in genomewide association studies; tools to analyze and reconstruct metabolic pathways, regulatory pathways, and signaling pathways through the use of gene expression data, protein-DNA interaction data, protein interaction data, protein complex data, sequence data, chromatin modification data, phenotype data, and other data types.
Education
Ph.D. in Statistics, University of California at Berkeley, 1995
Awards and Honors
Fellow, American Statistical Association, 2006
Elected Member, International Statistical Institute, 2006
Ira V. Hiscock Associate Professor, Yale University, 2001-2006
Basil O'Connor Starter Scholar Award, March of Dimes Foundation, 1991-2001
Evelyn Fix Memorial Medal and Citation, University of California at Berkeley, 1995
Professional Services
Associate Editor, Biometrics
Member, Genomics, Computational Biology and Technology (GCAT) Study Section (GCAT), NIH, 2005-2009
Member, Data Safety and Monitoring Board, Interaction of Genes and Environment in Shaping Risk Factors for Heart, Lung, Blood and Sleep Disorders, National Heart, Lung, and Blood Institute/NIH, 2003-2007
Board of Directors, International Chinese Statistical Association, 2003-2006
Member, Biostatistical Methods and Research Design (BMRD) Study Section (BMRD), National Institutes of Health (NIH), 2002-2004
Courses Taught
BIS/GEN 631a Topics in Genetic Epidemiology
BIS692b/STAT645b Statistical Methods in Genetics and Bioinformatics
Current Research Projects
Statistical and Computational Approaches for Integrated Genomics and Proteomics Analysis and Their Applications to Modeling G1/S Transition During Yeast Cell Cycle; Statistical Methods to Map Genes for Complex Traits; and Statistical Methods for Haplotype Analysis
Yale Affiliations
Associate Professor, Department of Genetics
Director, Yale Center for Statistical Genomics and Proteomics
Director, Biostatistics Resource, Keck Laboratory
In the News
Zhao Elected Fellow of the American Statistical Association
Zhao Author on Study of New Blood Test for Ovarian Cancer Screening
Selected Publications
Zuo, Y., Zou, G., and Zhao, H. Two-stage Designs in Case-control Association Analysis. Genetics, in press, 2006.
Pang, H., Lin, A., Holford, M., Emerson, B.E., Lu, B., Lawton, M.P., Floyed, E., and Zhao, H. Pathway Analysis Using Random Forests Classification and Regression. Bioinformatics, in press, 2006.
Sun, N., Carrol, R., and Zhao, H. Bayesian Error Analysis Model for Reconstructing Transcriptional Regulatory Networks. Proceedings of the National Academy of Sciences 103(21): 7988-7993, 2006.
Wang, S., Huang, S., Zheng, L., and Zhao, H. Mapping Quantitative Trait Loci in Non-inbred Mosquito Crosses. Genetics 172: 2293-2308, 2006.
Liu, N., Beerman, I., Lifton, R., and Zhao, H. Haplotype Analysis in the Presence of Informatively Missing Genotype Data. Genetic Epidemiology 30(4): 290-300, 2006.
For a further list of Dr. Zhao’s publications, please see Pub Med.
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