Elan D Louis, MD, MS

Professor of Neurology and of Epidemiology (Chronic Diseases); Chief, Division of Movement Disorders

Departments & Organizations

Neurology: Movement Disorders

School of Public Health: Chronic Disease Epidemiology

Center for Musculoskeletal Care

Center for Neuroepidemiology and Clinical Neurological Research

Lysosomal Disease & Inherited Metabolic Liver Disease Program

Yale Medicine

Biography

A graduate of University of Pennsylvania (BA, 1984), Yale Medical School (MD, 1989), and Columbia University School of Public Health (MS, Epidemiology, 1995), Dr. Louis joined the College of Physicians and Surgeons, Columbia University faculty in 1995 and was for many years a Professor of Neurology and Epidemiology before being recruited to Yale University in 2015 to be Chief of the Movement Disorders Division in the Department of Neurology. Dr. Louis’ principal academic interest is in degenerative diseases of the central nervous system, focusing on disorders of involuntary movement. He has a particular interest in essential tremor (ET), one of the most common neurological disorders, and his research efforts have focused on a broad spectrum of issues including its epidemiology, genetics, and underlying pathology. His work on ET has been cited in the New York Times as “pioneering” and he is considered to be the leading ET scholar in the world. Through his research, Dr. Louis has challenged many of the prevailing notions about ET and has substantially re-created the dialogue in the ET field. Dr. Louis established and currently leads the Essential Tremor Centralized Brain Repository, which is a national centralized brain bank for the study of ET, and has established a large DNA bank for patients with the disorder. He collaborates with investigators in Spain, Turkey, and Mexico examining the epidemiology of ET in these populations. He has received continuous funding from the National Institutes of Health (NIH) since 1995, as well as funding from the International Essential Tremor Foundation, the Charles A. Dana Foundation, the Parkinson's Disease Foundation, and a Paul Beeson Physician Faculty Scholars Award from the American Federation for Aging Research. He serves on the medical advisory board of the International Essential Tremor Foundation, the Tremor Action Network, and HopeNET. Dr. Louis is the author of over 500 peer-reviewed scientific publications and book chapters and has been invited to write editorials and reviews for Annals of Neurology, New England Journal of Medicine, and Lancet Neurology. He serves on the editorial board of more than ten scholarly peer-reviewed scientific journals and is the founding Editor-in-Chief of the peer-reviewed journal Tremor and Other Hyperkinetic Movements. He is also the current editor of Merritt’s Textbook of Neurology (13th Edition), the most longstanding textbook in the field of neurology. Dr. Louis is committed to the care of his patients with involuntary movements and he has been listed by Castle Connolly as one of the Top Doctors in the field of Neurology.

Education & Training

MS Columbia University (1995)
MD Yale University School of Medicine (1989)
BA University of Pennsylvania, Anthropology (1984)
Fellowship Columbia University
Fellowship Columbia University
Residency Neurological Institute of New York, Columbia University
Internship Yale-New Haven Hospital
Board Certification AB of Psychiatry & Neurology, Neurology (1994, recertified: 2014)

Honors & Recognition

  • H. Richard Tyler Award, awarded for historical research which utilizes the American Academy of Neurology Library Collection American Academy of Neurology (2011)

  • Lawrence C. McHenry Award, awarded for excellence in research in the history of neurologyAmerican Academy of Neurology (2010)

  • Lawrence C. McHenry Award, awarded for excellence in research in the history of neurology American Academy of Neurology (1994)

  • Outstanding Houseofficer and Teacher Columbia University (1992)

  • Cum LaudeYale University School of Medicine (1989)

  • Harold Lamport Biomedical Research Prize, presented for an outstanding thesis reporting original biomedical research Yale University School of Medicine (1989)

  • Merck Research Award, awarded to three outstanding graduating medical students Yale University School of Medicine (1989)

  • Dean's List for Academic DistinctionUniversity of Pennsylvania (1984)

  • Magna Cum LaudeUniversity of Pennsylvania (1984)

  • Dean's List for Academic DistinctionUniversity of Pennsylvania (1983)

  • Dean's List for Academic Distinction University of Pennsylvania (1982)

  • Dean's List for Academic DistinctionUniversity of Pennsylvania (1981)

  • Benjamin Franklin Honors Society NomineeUniversity of Pennsylvania (1981)

Professional Service

  • Basal Ganglia Journal - Editorial Board (2017)

  • Journal of Clinical Movement Disorders - Editorial Board (2015) Editorial Board

  • Cerebellum and Ataxias - Editorial Board Editorial board

  • International Journal of Neuropathology - Editorial Board Editorial Board

  • Frontiers in Movement Disorders - Editorial Board Editorial Board

  • Tremor and Other Hyperkinetic Movements - Editorial Board Editor-in-Chief

  • Journal of Neurology and Neurophysiology - Editorial Board Editorial Board

  • Journal of Neurology and Neuroscience - Editorial Board Editorial Board

  • Degenerative Neurological and Neuromuscular Disease - Editorial Board Editorial Board

  • Parkinson's Disease - Editorial Board Editorial Board

  • Neuroepidemiology - Editorial Board Editorial Board

  • The Open Environmental Journal - Editorial Board Editorial Board

  • Neural Regeneration Research - Editorial Board Editorial Board

  • Journal of the History of the Neurosciences - Editorial Board Editorial Board

  • Turkilye Klinikleri Journal of Medical Sciences - Editorial Board Editorial Board

Activities

  • XXII Congress of the International Association of Parkinsonism and Related Disorders Ho Chi Minh City, Vietnam (2017)

    "Revisiting essential tremor, then and now: Tracing the emergence of a complex disorder"

  • XXII Congress of the International Association of Parkinsonism and Related Disorders Ho Chi Minh City, Vietnam (2017)


    "The evolving definition of essential tremor"

  • Neurology Association of South Africa, Annual Congress, Bloemfontein, Republic of South Africa Bloemfontein, South Africa (2017)

    "The A,B,C's and Z's of Recognizing and Diagnosing Tremors"

  • Neurology Association of South Africa, Annual Congress, Bloemfontein, Republic of South Africa Bloemfontein, South Africa (2017)

    "Biology of Essential Tremor-Revealing the Underpinnings of One of the Most Common Neurodegenerative Diseases"

  • Neurology Association of South Africa, Annual Congress, Bloemfontein, Republic of South Africa Bloemfontein, South Africa (2017)

    “Searching for the Prime Mover of the Movers and Shakers: Recounting a 15 year Journey into the Environmental Epidemiology of Essential Tremor”

  • Aiginiteio Hospital, University of Athens, Athens, Greece Athens, Greece (2016)

    “Re-conceptualizing the Biology of Essential Tremor: Patho-mechanisms of One of the Most Common Neurodegenerative Diseases”

  • Invited Speaker, UCB Pharma, PD Expert Meeting, Mater Misericordiae University Hospital, Dublin, Ireland Dublin, Ireland (2016)

    "The A, B, Cs and Zs of Recognizing and Diagnosing Tremors"

  • Invited Speaker, Beaumont Hospital and Irish Institute of Clinical Neuroscience, Dublin, Ireland Dublin, Ireland (2016)

    "Re-conceptualizing the Biology of Essential Tremor - Patho-mechanisms of One of the Most Common Neurodegenerative Diseases"

  • Special Guest Lecturer, Neurophysiology: 12th Annual Update Conference Series & Clinical Neurology Jerusalem, Israel (2016)

    "Re-conceptualizing the Biology of Essential Tremor" and "The A, B, Cs and Zs of Recognizing and Diagnosing Tremors"

  • Keynote Speaker, 9th Annual Neuroscience Meeting, Laval University Quebec City, Canada (2015)

    "Biological Basis of Essential Tremor - Examining the Patho-mechanisms of the Most Common Neurodegenerative Disease"

  • Invited Speaker, 7th Symposium of the Society of Research on the Cerebellum Brussels, Belgium (2015)

    “Essential Tremor: A Common Disorder of the Cerebellum”

  • Invited Speaker, XXI World Congress on Parkinson's Disease and Related Disorders Milano, Italy (2015)

    "Tremor: Clinical Aspects" and "Non-motor Symptoms of Essential Tremor"

  • Invited Speaker, 4th International Congress on Neurology and Epidemiology Kuala Lumpur, Malaysia (2014)

    “Recent advances in the epidemiology of essential tremor”

  • Invited Speaker, Symposium on Current Approaches to the Treatment of Movement Disorders, Palacky University and Czech Movement Disorder Society Olomouc, Czech Republic (2013)

    “Waking the Sleeping Giant: The Rise of Essential Tremor Research”

  • Invited Speaker, XX World Congress on Parkinson’s Disease and Related Disorders Geneve, Switzerland (2013)

    “Re-thinking the Biology of Essential Tremor: From Models to Morphology”

  • Invited Speaker, Mexican Academy of Neurology Merida, Mexico (2013)

    “Re-thinking the Biology of Essential Tremor: From Models to Morphology”,

  • Inivted Speaker, Summer School of Neurorehabilitation La Alberca, Spain (2013)

    “Clinical Neurology: The A, B, Cs and Zs of Recognizing and Diagnosing Tremors”

  • Invited Speaker, 2nd International Congress on Neurology and Epidemiology Nice, France (2012)

    “Essential Tremor and Its Associations with Other Neurodegenerative Diseases: What is the Epidemiological Evidence?”

  • Keynote Speaker, Korean Movement Disorder Society Busan, South Korea (2012)

    “Biology of Essential Tremor”

  • Plenary Session Speaker, 16th International Congress of Parkinson’s Disease and Movement Disorders Dublin, Ireland (2012)

    “Essential Tremor is Predictive of Parkinson’s Disease”

  • Invited Speaker, Swiss Neurological Society Lugano, Switzerland (2012)

    “Essential Tremor: Is This a Neurodegenerative Disease?”

  • Invited Speaker, Institute of Neurology, Fudan University, Hua Shan Hospital Shanghai, China (2011)

    “Approach to the Shaky Patient: Diagnosis and Treatment of Tremor Disorders”

  • Invited Speaker, XIX World Congress on Parkinson’s Disease and Related Disorders Shanghai, China (2011)

    “Treatment of Essential Tremor”

  • Invited Speaker, New Zealand Conference on Stroke and Applied Neurosciences Auckland, New Zealand (2011)

    “New Insights into Essential Tremor: Recognizing a Broader Clinical Phenomenology and Discovering the Underlying
    Pathological Anatomy”

  • Invited Speaker, Movement Disorders Symposium, University Hospital Leuven Leuven, Belgium (2011)

    “Essential Tremor: New Insights into Disease Pathophysiology”

  • Invited Speaker, 15th International Congress of Parkinson’s Disease and Movement Disorders Toronto, Canada (2011)

    “Is Cognitive Impairment a Component of Essential Tremor?”

  • Invited Speaker, 29th International Congress of Clinical Neurophysiology Kobe-shi, Japan (2010)

    “Neuropathology of Essential Tremor”

  • Invited Speaker, 34th Reunión Anual de al Academia Mexicana de Neurología Leon, Mexico (2010)

    “Essential Tremor”

  • Invited Speaker, National Tremor Symposium Antioch, Turkey (2010)

    “Parkinsonian Tremor”, “Essential Tremor: Evolving Clinicopathological Concepts in an Era of Intensive Postmortem Inquiry”, “Etiology of Essential Tremor: Exploring the Environment for Causes of the Most Common Movement Disorder”

  • Invited Speaker, Department of Neurology, Hospital “12 de Octubre Madrid, Spain (2009)

    “The Essential Tremors: Recognizing a Broader Clinical Phenomenology and Discovering the Underlying Pathological Anatomy”

  • Invited Speaker, Grand Rounds, Centre hospitalier de l'Université de Montréal (CHUM), Hopital Notre Dame, Université de Montréal Montreal, Canada (2009)

    “The Essential Tremors: Recognizing a Broader Clinical Phenomenology and Discovering the Underlying Pathological Anatomy”

  • Invited Speaker, Movement Disorder Group, Montreal Neurological Institute, McGill University Montreal, Canada (2009)

    “The Essential Tremors: Recognizing a Broader Clinical Phenomenology and Discovering the Underlying Pathological Anatomy”

  • Invited Speaker, 6th International Congress on Mental Dysfunctions & Other Non-Motor Features of Parkinson’s Disease and Related Disorders Dresden, Germany (2008)

    “Dementia in Essential Tremor”

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Contact Info

Elan D Louis, MD, MS
Patient Care Locations
Yale NeurologyYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
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260 Long Ridge Road
Stamford, CT 06902
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Yale NeurologyYale-New Haven Hospital
20 York Street

New Haven, CT 06510
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Yale NeurologyYale-New Haven Hospital Saint Raphael Campus
1450 Chapel Street

New Haven, CT 06511
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Mailing Address
LCI 710
15 York Street, PO Box 208018

New Haven, CT 06520-8018
Research Image 1

Model of essential tremor pathogenesis

Research Image 2

Calbindin immunohistochemistry on 100 µm cerebellar neocortex sections, 100x. (A) Normal control brain with thin visible axonal profiles. (B) Three torpedoes (arrow heads), two of which are on axons with recurrent collaterals (carets). Several thickened axonal profiles are shown (short arrows). (C) Terminal axonal sprouting (thick arrow). (D) Arciform axon profile; profile is also thickened. (E) Torpedoes (arrow heads) with axonal recurrent collaterals (carets) and axonal branching (long arrows and inset). (F) A visible portion of the recurrent collateral plexus at the Purkinje cell layer (boxed). (G) Thickened axonal profiles (short arrows).