- As successful malaria control measures have been implemented, transmission in some regions has declined, resulting in a decrease in parasite diversity and the emergence and persistence of specific parasite genotypes in multiple individuals in the population. Using genetic and genomic techniques and a translational systems biology approach, we will determine whether the persistence of specific parasite genotypes is related to neutralizing genotype-specific immunity, enhanced transmission potential, or undiscovered asymptomatic reservoirs, ultimately allowing the development of targeted genotype-transcendent interventions.
- While malaria is treatable with chemotherapy, the emergence of drug-resistant parasites globally has made the development of an effective vaccine essential. Natural infection with the malaria parasite does not induce sterilizing immunity in humans, and vaccines to date show only modest efficacy. The process of malaria immunity is complex and dependent on many antigens with diverse alleles. To rationally prioritize vaccine candidates, it is essential to understand the impact of parasite diversity on functional immune responses. Rather than retrospectively assessing the impact of diversity, we seek to specifically test the role of naturally arising polymorphisms in blood stage vaccine candidate antigens on receptor binding and immune evasion before they reach late stage trials.
We are looking for scientists who have completed their PhD and have experience in one or more fields of Molecular Biology, Genetics (including CRISPR-Cas9 genome editing), Genomics, Immunology, Epidemiology, and/or Entomology. We are looking for a motivated and collaborative postdoctoral associate interested in both fundamental and applied questions in Malaria Biology – specifically in questions of host-pathogen interactions, systems biology, immunology, transmission, and epidemiology.
- PhD in a relevant subject area
- Knowledge of a range of research techniques and methodologies in both experimental and computational areas
- Ability to develop research objectives, projects and proposals independently
- Experience of carrying out both independent and collaborative research
- Highly developed communication skills to engage effectively with a wide-ranging audience, both orally and in writing, using a range of media
- Interest in and enthusiasm for the subject matter of the project, and science in general!
- Combine cutting-edge laboratory techniques in a vibrant and collegial academic setting with the ability to study disease dynamics in real-time in the field
- Training in genomics, systems biology, experimental genetics and immunoepidemiology
- Opportunities to work at our collaborative field research sites in Senegal
Interested applicants should submit a CV, a cover letter outlining research interests and qualifications, and contact information for 3 references.
Yale University is an Affirmative Action/Equal Opportunity Employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.