Feng Dai, PhD, MS

Research Interests

Anesthesia and Analgesia; Cardiovascular Diseases; Pain; Health Care

Public Health Interests

Biostatistics; Genetic epidemiology

Research Organizations

School of Public Health: Yale Center for Analytical Sciences (YCAS)

Selected Publications

• Is There Evidence for Systematic Upcoding of ASA Physical Status Coincident with Payer Incentives? A Regression Discontinuity Analysis of the National Anesthesia Clinical Outcomes Registry.

  Schonberger RB, Dutton RP, Dai F (2016) Anesth Analg. 122(1):243-50.

• Handoffs in the Postoperative Anesthesia Care Unit: Use of a Checklist for Transfer of Care.

  Robins HM, Dai F (2015) AANA J 83(4):264-8.

• The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.

  Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS. Sci Transl Med. 2015 May 13;7(287):287ra72

• Integration of pain score and morphine dose in analgesic clinical studies

  Dai F, et al. (2013) Journal of Pain, 14(8):767-777

• Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease

  Dai F, et al. (2010) The Spine Journal, 10(1):949-957

• Phenotyping and Genotyping Neuropathic Pain. Current Pain and Headache Reports

  Belfer I and Dai F (2010) Current Pain and Headache Reports, 14:203–212

• A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene

  Neely GG1, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM (2010) Cell. 143(4):628-3

• Ordered Genotypes: An Extended ITO Method and a General Formula for Genetic Covariance

  Dai F and Weeks DE (2006) Am J Hum Genet. 2006 June; 78(6): 1035–1045

Full List of PubMed Publications

• Meng L, Gruenbaum SE, Dai F, Wang T: Physiology, intervention, and outcome: three critical questions about cerebral tissue oxygen saturation monitoring. Minerva Anestesiol. 2018 May; 2018 Jan 17. PMID: 29343048
• Snegovskikh D, Souza D, Walton Z, Dai F, Rachler R, Garay A, Snegovskikh VV, Braveman FR, Norwitz ER: Corrigendum to "Point-of-care viscoelastic testing improves the outcome of pregnancies complicated by severe postpartum hemorrhage" [J Clin Anesth 44(2018) 50-56]. J Clin Anesth. 2018 Apr 15; 2018 Apr 15. PMID: 29669303
• Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R: Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. J Clin Invest. 2018 Apr 2; 2018 Mar 5. PMID: 29381484
• Chen EY, Sukumar N, Dai F, Akhtar S, Schonberger RB: A Pilot Analysis of the Association Between Types of Monitored Anesthesia Care Drugs and Outcomes in Transfemoral Aortic Valve Replacement Performed Without General Anesthesia. J Cardiothorac Vasc Anesth. 2018 Apr; 2017 Jul 12. PMID: 29277298
• Pak VM, Dai F, Keenan BT, Gooneratne NS, Pack AI: Lower plasma choline levels are associated with sleepiness symptoms. Sleep Med. 2018 Apr; 2017 Oct 26. PMID: 29530375
• Wang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C, LaMotte RH: Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. Neurosci Lett. 2018 Mar 6; 2018 Feb 3. PMID: 29355697
• Lee Y, Blount KL, Dai F, Thompson S, Scher JK, Bitterman S, Droher M, Herzog EL, Moeckel G, Karihaloo A, Dahl NK: Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment. Clin Exp Nephrol. 2018 Feb 16; 2018 Feb 16. PMID: 29453607
• Schonberger RB, Nwozuzu A, Zafar J, Chen E, Kigwana S, Monteiro MM, Charchaflieh J, Sophanphattana S, Dai F, Burg MM: Elevated preoperative blood pressures in adult surgical patients are highly predictive of elevated home blood pressures. J Am Soc Hypertens. 2018 Feb 6; 2018 Feb 6. PMID: 29486981
• Snegovskikh D, Souza D, Walton Z, Dai F, Rachler R, Garay A, Snegovskikh VV, Braveman FR, Norwitz ER: Point-of-care viscoelastic testing improves the outcome of pregnancies complicated by severe postpartum hemorrhage. J Clin Anesth. 2018 Feb; 2017 Nov 7. PMID: 29121548
• Tantawy H, Li A, Dai F, Elgammal M, Sukumar N, Elefteriades J, Akhtar S: Association of red blood cell transfusion and short- and longer-term mortality after coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2017 Dec 21; 2017 Dec 21. PMID: 29402623
• Hwang JJ, Jiang L, Hamza M, Sanchez Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS: Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight. 2017 Oct 19; 2017 Oct 19. PMID: 29046482
• Gruenbaum SE, Toscani L, Fomberstein KM, Ruskin KJ, Dai F, Qeva E, Rosa G, Meng L, Bilotta F: Severe Intraoperative Hyperglycemia Is Independently Associated With Postoperative Composite Infection After Craniotomy: An Observational Study. Anesth Analg. 2017 Aug. PMID: 28181933
• Schonberger RB, Dai F, Brandt C, Burg MM: The effect of race on postsurgical ambulatory medical follow-up among United States Veterans. J Clin Anesth. 2017 Aug. PMID: 28625448
• Khalil H, Sereika SM, Dai F, Alexander S, Conley Y, Gruen G, Meng L, Siska P, Tarkin I, Henker R: OPRM1 and COMT Gene-Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma. Biol Res Nurs. 2017 Mar; 2016 Nov 30. PMID: 27903758
• Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS: The human brain produces fructose from glucose. JCI Insight. 2017 Feb 23; 2017 Feb 23. PMID: 28239653
• Liu LY, Craiglow BG, Dai F, King BA: Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients. J Am Acad Dermatol. 2017 Jan; 2016 Nov 2. PMID: 27816293
• Akhtar S, Heng J, Dai F, Schonberger RB, Burg MM: A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients? Drugs Aging. 2016 Oct. PMID: 27581549
• Akhtar S, Liu J, Heng J, Dai F, Schonberger RB, Burg MM: Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice. J Clin Anesth. 2016 Sep; 2016 May 3. PMID: 27555166
• Wiznia DH, Kim CY, Dai F, Goel A, Leslie MP: The effect of helmets on motorcycle outcomes in a level I trauma center in Connecticut. Traffic Inj Prev. 2016 Aug 17; 2016 Feb 18. PMID: 26889888
• Wiznia L, Dai F, Chagpar AB: Do non-melanoma skin cancer survivors use tanning beds less often than the general public? Dermatol Online J. 2016 Aug 15; 2016 Aug 15. PMID: 27617935
• Alian AA, Atteya G, Gaal D, Golembeski T, Smith BG, Dai F, Silverman DG, Shelley K: Ventilation-Induced Modulation of Pulse Oximeter Waveforms: A Method for the Assessment of Early Changes in Intravascular Volume During Spinal Fusion Surgery in Pediatric Patients. Anesth Analg. 2016 Aug. PMID: 27284998
• Scheinost D, Kwon SH, Shen X, Lacadie C, Schneider KC, Dai F, Ment LR, Constable RT: Preterm birth alters neonatal, functional rich club organization. Brain Struct Funct. 2016 Jul; 2015 Sep 4. PMID: 26341628
• Schonberger RB, Dai F, Brandt C, Burg MM: Ambulatory Medical Follow-Up in the Year After Surgery and Subsequent Survival in a National Cohort of Veterans Health Administration Surgical Patients. J Cardiothorac Vasc Anesth. 2016 Jun; 2015 Dec 15. PMID: 27021176
• Ghogawala Z, Dziura J, Butler WE, Dai F, Terrin N, Magge SN, Coumans JV, Harrington JF, Amin-Hanjani S, Schwartz JS, Sonntag VK, Barker FG 2nd, Benzel EC: Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis. N Engl J Med. 2016 Apr 14. PMID: 27074067
• Henderson MX, Wirak GS, Zhang YQ, Dai F, Ginsberg SD, Dolzhanskaya N, Staropoli JF, Nijssen PC, Lam TT, Roth AF, Davis NG, Dawson G, Velinov M, Chandra SS: Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Acta Neuropathol. 2016 Apr; 2015 Dec 10. PMID: 26659577
• Urday S, Beslow LA, Dai F, Zhang F, Battey TW, Vashkevich A, Ayres AM, Leasure AC, Selim MH, Simard JM, Rosand J, Kimberly WT, Sheth KN: Rate of Perihematomal Edema Expansion Predicts Outcome After Intracerebral Hemorrhage. Crit Care Med. 2016 Apr. PMID: 26757167
• Kwon SH, Scheinost D, Vohr B, Lacadie C, Schneider K, Dai F, Sze G, Constable RT, Ment LR: Functional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long-lasting changes in language organization. Dev Med Child Neurol. 2016 Mar. PMID: 27027605
• Schonberger RB, Dutton RP, Dai F: Is There Evidence for Systematic Upcoding of ASA Physical Status Coincident with Payer Incentives? A Regression Discontinuity Analysis of the National Anesthesia Clinical Outcomes Registry. Anesth Analg. 2016 Jan. PMID: 26360960
• Dai F, Xu Y: Letter to the Editor: Experimental Comparison of Parametric Versus Nonparametric Analyses of Data From the Cold Pressor Test. J Pain. 2016 Jan. PMID: 26721379
• Schonberger RB, Dai F, Brandt CA, Burg MM: Balancing Model Performance and Simplicity to Predict Postoperative Primary Care Blood Pressure Elevation. Anesth Analg. 2015 Sep. PMID: 26214552
• Wood SG, Dai F, Dabu-Bondoc S, Mikhael H, Vadivelu N, Duffy A, Roberts KE: Transvaginal cholecystectomy learning curve. Surg Endosc. 2015 Jul; 2014 Oct 8. PMID: 25294548
• Kwon SH, Scheinost D, Lacadie C, Sze G, Schneider KC, Dai F, Constable RT, Ment LR: Adaptive mechanisms of developing brain: cerebral lateralization in the prematurely-born. Neuroimage. 2015 Mar; 2014 Dec 17. PMID: 25528658
• Belfer I, Dai F, Kehlet H, Finelli P, Qin L, Bittner R, Aasvang EK: Association of functional variations in COMT and GCH1 genes with postherniotomy pain and related impairment. Pain. 2015 Feb. PMID: 25599448
• Kim CY, Wiznia DH, Averbukh L, Dai F, Leslie MP: The Economic Impact of Helmet Use on Motorcycle Accidents: A Systematic Review and Meta-analysis of the Literature from the Past 20 Years. Traffic Inj Prev. 2015; 2015 Apr 28. PMID: 25919856
• Schonberger RB, Feinleib J, Holt N, Dai F, Brandt C, Burg MM: Preoperative depression symptom severity and its impact on adherence to preoperative beta-blocker therapy. J Cardiothorac Vasc Anesth. 2014 Dec; 2014 Sep 26. PMID: 25263776
• Safavi KC, Dai F, Gilbertsen TA, Schonberger RB: Variation in surgical quality measure adherence within hospital referral regions: do publicly reported surgical quality measures distinguish among hospitals that patients are likely to compare? Health Serv Res. 2014 Aug; 2014 Mar 11. PMID: 24611578
• Saglam O, Dai F, Husain S, Zhan Y, Toruner G, Haines GK 3rd: Matricellular protein CCN1 (CYR61) expression is associated with high-grade ductal carcinoma in situ. Hum Pathol. 2014 Jun; 2014 Feb 20. PMID: 24767859
• Schonberger RB, Gilbertsen T, Dai F: The problem of controlling for imperfectly measured confounders on dissimilar populations: a database simulation study. J Cardiothorac Vasc Anesth. 2014 Apr; 2013 Aug 17. PMID: 23962461
• Kurup V, Dabu-Bondoc S, Senior A, Dai F, Hersey D, Vadivelu N: Concern for pain in the pre-operative period- is the internet being used for information by patients? Pain Pract. 2014 Feb; 2013 May 22. PMID: 23692356
• Odonkor CA, Schonberger RB, Dai F, Shelley KH, Silverman DG, Barash PG: New utility for an old tool: can a simple gait speed test predict ambulatory surgical discharge outcomes? Am J Phys Med Rehabil. 2013 Oct. PMID: 24051992
• Dabu-Bondoc S, Vadivelu N, Shimono C, English A, Kosarussavadi B, Dai F, Shelley K, Feinleib J: Intravenous dextrose administration reduces postoperative antiemetic rescue treatment requirements and postanesthesia care unit length of stay. Anesth Analg. 2013 Sep; 2012 Jan 17. PMID: 22253268
• Dai F, Silverman DG, Chelly JE, Li J, Belfer I, Qin L: Integration of pain score and morphine consumption in analgesic clinical studies. J Pain. 2013 Aug; 2013 Jun 3. PMID: 23743256
• Schonberger RB, Brandt C, Feinleib J, Dai F, Burg MM: Atenolol is associated with lower day-of-surgery heart rate compared to long- and short-acting metoprolol. J Cardiothorac Vasc Anesth. 2013 Apr; 2012 Aug 11. PMID: 22889605
• Schonberger RB, Burg MM, Holt N, Lukens CL, Dai F, Brandt C: The relationship between preoperative and primary care blood pressure among veterans presenting from home for surgery: is there evidence for anesthesiologist-initiated blood pressure referral? Anesth Analg. 2012 Jan; 2011 Nov 10. PMID: 22075017

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