Center for Methods in Implementation and Prevention Science (CMIPS)

Yale School of Public Health's new Center for Methods in Implementation and Prevention Science (CMIPS) was created to develop and disseminate innovative methodologic approaches to address these implementation gaps and directly improve health outcomes worldwide.

A mere 14 percent of biomedical research is ever translated into practice, and among these 17 years pass on average from the time a research article is submitted to eventual implementation. Cervical cancer, for example, is now uncommon in North America and Western Europe, but it remains a leading cause of cancer mortality among women in low- and middle-income countries. Similar patterns exist for HIV/AIDS and other diseases.

• October 16, 2020: Donna Spiegelman, ScD, Susan Dwight Bliss Professor of Biostatistics, Yale School of Public Health (YSPH), and Ariel Chao, MPH, PhD Candidate, Department of Biostatistics, YSPH, speak virtually to Amherst College statistics and mathematics majors about biostatistics graduate programs at Yale.
• June 1, 2021: Rafael Perez-Escamilla, PhD, Professor of Public Health (Social and Behavioral Sciences), Yale School of Public Health, Invited Kellogg Prize for Lifetime Achievements in International Nutrition Award Lecturer at Nutrition 2021 Conference in Boston, MA

• Allore H, Goldfeld K, Gutman R, Li F, Monin J, Taljaard M, Travison T. Statistical considerations for embedded pragmatic clinical trials in people living with dementia. Journal of the American Geriatrics Society. 2020;68(S2):S68-S73.
• Aryeetey R, Lasisi O, Hromi-Fiedler A, Carroll G, Pérez-Escamilla R, Harding K. Design and testing of communication materials for a breastfeeding social media marketing campaign: Breastfeed4Ghana. Digit Health. 2020 Mar 16;6.
• Barnhart D, Semrau K, Zigler C, Molina R, Delaney M, Hirschhorn L, Spiegelman D. Optimizing the development and evaluation of complex interventions: Lessons learned from the BetterBirth Program and associated trial. Implementation Science Communications. 2020. Accepted.
• Bellows AL, Spiegelman D, Du S, Jaacks LM. The association of cooking fuel use, dietary intake, and blood pressure among rural women in China. International Journal of Environmental Research and Public Health. 2020;17(15):E5516.
• Bhattarai S, Aryal A, Pyakurel M, Bajracharya S, Baral P, Citrin D, Cox H, Dhimal M, Fitzpatrick A, Jha AK, Jha N, Karmacharya BM, Koju R, Maharjan R, Oli N, Pyakurel P, Sapkota BP, Shrestha R, Shrestha S, Spiegelman D, Vaidya A, Shrestha A. Cardiovascular disease trends in Nepal - An analysis of global burden of disease data 2017. International Journal of Cardiology Heart & Vasculature. 2020 Oct;30:100602.
• Boeke CE, Khan S, Walsh F, Hettema A, Lejeune C, Spiegelman D, Okello V, Harwell J, Mazibuko S, Bärnighausen T. Universal test and treat in relation to HIV disease progression: Results from a stepped-wedge trial in Eswatini. HIV Medicine. Accepted Jul 2020.
• Brault MA, Spiegelman D, Karim SSA, Vermund SH. Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials. Current HIV/AIDS Reports. 2020; 17(3):249-258.
• Buccini G, Harding KL, Ferré Eguiluz I, Safon CB, Hromi-Fielder A, González de Cosío T, Pérez-Escamilla R. An analysis of stakeholder networks to support the breastfeeding scale-up environment in Mexico. J Nutr Sci. 2020 Mar 9;9:e10.
• Byanjankar P, Poudyal A, Kohrt BA, Maharjan SM, Hagaman A, van Heerden A. Utilizing passive sensing data to provide personalized psychological care in low-resource settings. Gates Open Research. 2020. In press.
• Chao A, Spiegelman D, Khan S, Walsh F, Mazibuko S, Pasipamire M, Chai B, Reis R, Mlambo K, Delva W, Khumalo G, Zwane M, Fleming Y, Mafara E, Hettema A, Lejeune C, Bärnighausen T, Okello V. Mortality under early access to antiretroviral therapy vs. Eswatini’s national standard of care: the MaxART clustered randomized stepped-wedge trial. HIV Med. 2020;21(7):429-440.
• Chung E, Hagaman AK, LeMasters K, Andrabi N, Gallis J, Turner E, Sikander S, Maselko J. The impact of grandmother involvement on child growth and development in rural Pakistan. BMC Global Health. 2020. In press.
• Dambach P, Mahenga B, Mashasi I, Muya A, Bärnighausen TW, Spiegelman D, Harling G. Socio-Demographic Characteristics and Risk Factors for HIV Transmission in Female Bar Workers in Sub-Saharan Africa: A Systematic Literature Review. BMC Public Health. 2020; 20(1):697.
• Eilers MA, Hendrick CE, Pérez-Escamilla R, Powers DA, Potter JE. Breastfeeding Initiation, Duration, and Supplementation Among Mexican-Origin Women in Texas. Pediatrics. 2020 Apr;145(4):e20192742.
• Gallis JA, Li F, Turner EL. A command for bias-corrected sandwich variance estimation for GEE analyses of cluster randomized trials. The Stata Journal. 2020. Accepted.
• Ganmaa D, Uyanga B, Zhou X, Gantsetseg G, Delgerekh B, Enkhmaa D, Khulan D, Ariunzaya S, Sumiya E, Bolortuya B, Yanjmaa J, Enkhtsetseg T, Munkhzaya A, Tunsag M, Khudyakov P, Seddon J, Marais BJ, Batbayar O, Erdenetuya G, Spiegelman D, Amarsaikhan B, Tsolmon J, Martineau AR. Vitamin D supplementation to prevent Tuberculosis infection and disease. New England Journal of Medicine. 2020;383:359-368.
• Hagaman AK, Singh K, Abate M, Alemu H, Kefale A, Bitewulign B, Estifanos A, Kiflie A, Mulissa Z, Seman Y, Tadesse M, Tiyo H, Magge H. The impacts of quality improvement on maternal and newborn health: preliminary findings from a health system integrated intervention in four Ethiopian regions. BMC Health Services Research 20 (2020): 1-12.
• Hagaman AK, Baranov V, Chung E, LeMasters K, Andrabi N, Bates LM, Rahman A, Sikander S, Turner E, Maselko J. Social determinants of child HPA-Axis biomarkers at one year: Findings from rural Pakistan. Journal of Affective Disorders. 2020. In press.
• Khan S, Spiegelman D, Walsh F, Mazibuko S, Pasipamire M, Chai B, Reis R, Mlambo K, Delva W, Khumalo G, Zwane M, Fleming Y, Mafara E, Hettema, Lejeune C, Chao A, Bärnighausen T, Okello V. Early access to antiretroviral therapy versus standard of care among HIV-positive participants in Eswatini in the public health sector: the MaxART stepped-wedge randomized controlled trial. Journal of the International AIDS Society. Accepted Jul 2020.
• Koju P, Shakya PR, Shrestha A, Karmacharya BM, Shrestha S, Jaacks LM. Pilot educational intervention to promote safe pesticide use practices among farmworkers in Nepal. Annals of Work Exposures and Health. 3 Jun 2020. doi.org/10.1093/annweh/wxaa054.
• Le Masters K, Andrabi N, Zalla L, Hagaman AK, Chung E, Bates LM, Bhalotra S, Rahman A, Sikander S, Turner L, Maselko A. Cultural postpartum practices and depression in rural Pakistan. BMC Public Health. In press.
• Li F. Comment: Stabilizing the doubly-robust estimators of the average treatment effect under positivity violations. Statistical Science. 2020. Accepted.
• Li F, Allen AS. Secondary analysis of case-control association studies: Insights onweighting-based inference motivate a new specification test. Statistics in Medicine. Published online 5 June 2020.
• Li F, Harhay MO. Commentary: Right truncation in cluster randomized trials can attenuate the power of a marginal analysis. International Journal of Epidemiology. June 2020;49(3):964–967.
• Li F, Hughes JP, Hemming K, Taljaard M, Melnick ER, Heagerty PJ. Mixed-effects models for the design and analysis of stepped wedge cluster randomized trials: An overview. Statistical Methods in Medical Research. 2020. Accepted.
• Li KT, Huang W, Tang W, Wu F, Zhao Y, Wu D, Yang F, Zhang TP, Forastiere L, Alexander M, Kumar N, Tucker JD. A secondary mixed methods analysis of a pay-it-forward gonorrhea/chlamydia testing program among men who have sex with men in China. Sexually Transmitted Diseases. 2020;47(6):395-401.
• Lu L , Li F , Wen H, Ge S, Zeng J, Luo W, Wang L, Tang C, Xu N (2020). An evidence mapping and analysis of registered COVID-19 clinical trials in China. BMC Medicine. 2020;18(167):1-10.
• McClane B, Shrestha A. Using more than 1 (path)way to kill a host cell: lessons from Clostridium perfringens Enterotoxin. Microbiology Insights. 2020;13:1178636120931518.
• McGee EE, Kim CH; Wang M, Spiegelman D, Stover DG, Heng YJ, Collins LC, Baker GM, Farvid MS, Schedin P, Jindal S, Tamimi RM, Eliassen AH. Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. Breast Cancer Research. 2020; 22:78.
• Meyer AJ, Armstrong-Hough M, Babirye D, Mark D, Turimumahoro P, Ayakaka I, Haberer JE, Katamba A, Davis JL. Implementing mHealth interventions in a resource-constrained setting: case study from Uganda. JMIR mHealth uHealth. 2020;8(7):e19552.
• Musiimenta A, Tumuhimbise W, Atukunda EC, Mugaba AT, Muzoora C, Armstrong-Hough M, Bangsberg D, Davis JL, Haberer JE. Mobile health technologies may be acceptable tools for providing social support to tuberculosis patients in rural Uganda: a parallel mixed-method study. Tuberc Res Treat. 2020;2020:7401045.
• Nalugwa T, Shete PB, Nantale M, Farr K, Ojok C, Ochom E, Mugabe F, Joloba M, Dowdy DW, Moore DAJ, Davis JL, Cattamanchi A, Katamba A. Challenges with scale-up of GeneXpert MTB/RIF® in Uganda: a health systems perspective. BMC Health Serv Res. 2020;20(1):162.
• Nevo D, Lok J, Spiegelman D. Analysis of “Learn-As-You-Go” (LAGO) Studies. Annals of Statistics. 2020. Accepted.
• Noor RA, Abioye A, Hertzmark E, Darling AM, Aboud S, Mugusi F, Sudfield C, Spiegelman D, Fawzi W. Impaired hematological status is associated with mortality among HIV-infected adults initiating HAART in Tanzania. Journal of Nutrition. 2020 Jul 4;nxaa172.
• Pérez-Escamilla R, Cunningham K, Moran VH. COVID-19 and maternal and child food and nutrition insecurity: a complex syndemic. Matern Child Nutr. 2020 Jul;16(3):e13036.
• Pérez-Escamilla R, Segura-Pérez S. Can a pragmatic responsive feeding scale be developed and applied globally? Matern Child Nutr. 2020 Jul;16(3):e13004.
• Pescarini JM, Williamson E, Ichihara MY, Fiaccone RL, Forastiere L, Ramond A, Nery JS, Penna MLF, Strina A, Reis S, Smeeth L, Rodrigues LC, Brickley EB, Penna GO, Barreto ML. Conditional cash transfer program and leprosy incidence: analysis of 12.9 million families from the 100 Million Brazilian Cohort. American journal of epidemiology. 2020 Jul 8;kwaa127.
• Pujól von Seehausen M, Pérez-Escamilla R, Couto de Oliveira MI, do Carmo Leal M, Siqueira Boccolini C. Social support modifies the association between pre- pregnancy body mass index and breastfeeding initiation in Brazil. PLoS One. 2020 May 21;15(5):e0233452.
• Pyakurel P, Shrestha A, Karmacharya BM, Budhathoki SS, Chaudhari RK, Tamrakar D, Shrestha A, Karmacharya RM, Shrestha A, Sharma S, Sharam SK, Spiegelman D. Worksite intervention study to prevent diabetes in Nepal. BMJ Open Heart. Accepted Jul 2020.
• Reza TF, Nalugwa T, Farr K, Nantale M, Oyuku D, Nakaweesa A, Musinguzi J, Vangala M, Shete PB, Tucker A, Ferguson O, Fielding K, Sohn H, Dowdy D, Moore DAJ, Davis JL, Ackerman SL, Handley MA, Katamba A, Cattamanchi A. Study protocol: a cluster randomized trial to evaluate the effectiveness and implementation of onsite GeneXpert testing at community health centers in Uganda (XPEL-TB). Implementation Science. 2020;15(1):24.
• Shrestha A, Bhattarai S, Aryal A, Pyakurel M, Vaidya A, Jha AK, Fitzpatrick A, Sapkota BP, Karmacharya BM, Citrin D, Spiegelman D, Cox H, Dhimal M, Oli N, Jha N, Baral P, Pyakurel P, Shrestha R, Koju R, Maharjan R, Shrestha S, Bajracharya S. Cardiovascular disease trends in Nepal - An analysis of global burden of disease data 2017. Int J Cardiol Heart Vasc. 2020 Jul 31;30:100602.
• Vilar-Compte, M., Pérez, V., Teruel, G, Pérez-Escamilla. R. Costing of actions to safeguard vulnerable Mexican households with young children from the consequences of COVID-19 social distancing measures. Int J Equity Health. 2020 May 19;19(1):70.
• Vilar-Compte M, Pérez V, Teruel G, Alonso A, Pérez-Escamilla R. Costing of actions to safeguard vulnerable Mexican households with young children from the consequences of COVID-19 social distancing measures. Int J Equity Health. 2020 May 19;19(1):70.
• Vilar-Compte M, Pérez-Escamilla R, Moncada M, Flores D. How much can Mexican healthcare providers learn about breastfeeding through a semi-virtual training? A propensity score matching analysis. Int Breastfeed J. 2020 Jun 29;15(1):59.
• Vilar-Compte M, Teruel GM, Flores-Peregrina D, Carroll GJ, Buccini GS, Perez-Escamilla R. Costs of maternity leave to support breastfeeding; Brazil, Ghana and Mexico. Bull World Health Organ. 2020 Jun 1;98(6):382-393.
• Wagner J, Armeli S, Tennen H, Bermudez-Millan A, Wolpert H, Pérez-Escamilla R. A daily study of stressors, continuously measured glucose, and diabetes symptoms in latinos with type 2 diabetes. J Behav Med. 2020 Jun 3.
• Whittemore R, Vilar-Compte M, De La Cerda S, Delvy R, Jeon S, Burrola-Méndez S, Pardo-Carrillo M, Lozano-Marrufo A, Pérez-Escamilla R. ¡Sí, Yo Puedo Vivir Sano con Diabetes! A Self-Management Randomized Controlled Pilot Trial for Low-Income Adults with Type 2 Diabetes in Mexico City. Curr Dev Nutr. 2020 Apr 14;4(5).
• Xu DR, Dev R, Shrestha A, Zhang L, Shrestha A, Shakya P, Hughes JP, Shakya PR, Li J, Liao J, Karmacharya BM. NUrse-led COntinuum of care for people with Diabetes and prediabetes (NUCOD) in Nepal: study protocol for a cluster randomized controlled trial. Trials. 2020;21(1):442.
• Yang S, Li F, Starks MA, Hernandez AF, Mentz RJ, Choudhury KR. Sample size requirements for detecting treatment effect heterogeneity in cluster randomized trials. Statistics in Medicine. 2020. Accepted.
• Yu H, Li F, Turner EL. An evaluation of quadratic inference functions for estimating intervention effects in cluster randomized trials. Contemporary Clinical Trials Communications. 2020. Accepted.
• Yu H, Tong G, Li F. A note on the estimation and inference with quadratic inference functions for correlated outcomes. Communications in Statistics - Simulation and Computation. 2020. Accepted.

• Implementation Science Group (ISG)- a YSPH student group.
• Yale Center for Implementation Science (YCIS)