Erol Fikrig, MD

Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis; Investigator, Howard Hughes Medical Institute; Section Chief, Infectious Diseases

Departments & Organizations

Internal Medicine: Infectious Diseases: Fikrig Lab | Liver Center | Rheumatic Diseases Research Core

Microbial Pathogenesis

School of Public Health: Epidemiology of Microbial Diseases

Human and Translational Immunology Program

Molecular Virology: Virology Laboratories

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology | Microbiology

Yale Medicine

Global Health Studies

Office of Cooperative Research


My laboratory investigates vector-borne diseases. Studies are directed toward understanding Lyme disease, Human granulocytic ehrlichiosis, and West Nile virus. Efforts on Lyme disease include exploring immunity to Borrelia burgdorferi, selective B. burgdorferi gene expression in vivo, and the immunobiology of Lyme arthritis. Human granulocytic ehrlichiosis is caused by a newly described pathogen, transmitted by Ixodes scapularis ticks, that persists within neutrophils. We are investigating the molecular strategies that this pathogen uses to survive in polymorphonuclear leukocytes. West Nile virus can cause fatal encephalitis, and we seek to understand the pathogenesis of this emerging disease. Finally, we are also developing molecular approaches to prevent ticks from feeding on a mammalian host, thereby interfering with pathogen transmission.

Education & Training

MD Cornell University (1985)
BA Cornell University (1981)
Resident Vanderbilt University Hospital
Fellow Yale University School of Medicine
Board Certification AB of Internal Medicine, Internal Medicine (1988)


  • West-Nile Virus Protein Canada (2010)

    Yale and McGill University scientists have identified a protein that is critical in fighting mosquito-borne West Nile Virus in mice. This finding could have therapeutic implications for controlling the potentially deadly virus in humans. The study appears in the Advance Online Publication of Nature...

  • Pathogenesis of Lyme Disease Netherlands; Netherlands (2007)

    The goal of this project is to determine how specific components of the Lyme disease agent, Borrelia burgdorferi, and its arthropod vector, Ixodes ticks, contribute to the pathogenesis of Lyme disease in Europe.

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Contact Info

Erol Fikrig, MD
Patient Care Location
Yale New Haven Hospital
20 York Street

New Haven, CT 06510
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Office Location
The Anlyan Center
300 Cedar Street, Ste S525A

New Haven, CT 06519
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Mailing Address
Infectious DiseasesPO Box 208031
300 Cedar Street

New Haven, CT 06520-8056