Sunil Parikh, MD, MPH

Associate Professor of Epidemiology (Microbial Diseases) and of Medicine (Infectious Diseases)

Research Interests

Africa; Burkina Faso; Developing Countries; Epidemiology; Malaria; Nigeria; Parasitic Diseases; Public Health; Uganda; Global Health; Infectious Disease Medicine

Public Health Interests

Child health; Clinical Trials; Developing Countries (health); Epidemiology Methods; Genetic epidemiology; Global Health; Human genetic data; Immune functions; Infectious Disease; Malaria; Parasitology; Pregnancy

Research Organizations

School of Public Health: Center for Interdisciplinary Research on AIDS | Epidemiology of Microbial Diseases | YSPH Global Health Concentration

Infectious Diseases

MacMillan Center: African Studies

Office of Cooperative Research

Yale Institute for Global Health

Research Summary

Professor Parikh’s research interests focus on translational studies of malaria in sub-Saharan Africa. Dr. Parikh focuses upon several aspects of malaria: early host immune responses to infection, human genetics, and treatment. Current projects include: (1) understanding host factors affecting response to artemisinin-based antimalarial therapies using a combination of individual and population-based pharmacologic approaches to inform treatment guidelines; 2) characterizing the impact of host genetic and transcriptional variability in early immune responses to malaria; and 3) understanding the impact of the HIV epidemic on the treatment of malaria in co-endemic regions. Dr. Parikh has ongoing projects in several African countries, including Uganda, Burkina Faso, and Nigeria.

Specialized Terms: Translation research in malaria; Pharmacology of antimalarials; HIV-malaria co-infection; Host response to malaria infection; Innate immunity to malaria

Extensive Research Description

1) Antimalarial Therapy in the context of pregnancy, growth/development, and HIV coinfection in Uganda

Major Goal: To assess the pharmacokinetics and pharmacodynamics of artemisinin-combination therapies and their impact upon efficacy and drug resistance in vulnerable populations

2) Innate Immune Responses in Populations with Differing Susceptibility to Malaria in Burkina Faso

Major Goal: Through the study of early transcriptional and functional cellular responses in two ethnic groups with differing susceptibility to malaria, we will identify the key innate pathways which underlie this differential ability to control parasitemia

3) Antimalarial-Antiretroviral Drug Interaction studies in Nigeria, Tanzania, and Malawi

4) Dynamic Malaria Modelling in conjunction with the Galvani group

Selected Publications

Full List of PubMed Publications

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Contact Info

Sunil Parikh, MD, MPH
Patient Care Location
Yale Infectious DiseasesYale New Haven Hospital
20 York Street

New Haven, CT 06510
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Lab Location
60 College Street, Ste 7th floor
New Haven, CT 06510
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Office Location
60 College Street, Ste 724
New Haven, CT 06510
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Mailing Address
Epidemiology of Microbial Diseases60 College Street
P.O. Box 208322

New Haven, CA 06520