I. George Miller Jr, MD
John F. Enders Professor of Pediatrics (Infectious Disease) and Professor of Epidemiology (Microbial Diseases) and of Molecular Biophysics and Biochemistry; Section Chief, Pediatric Infectious Diseases
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Biography
Dr. Miller’s laboratory studies the mechanisms underlying the switch between latency and lytic replication of two oncogenic herpesviruses, Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus. Current experiments explore how viral and cellular transcription factors that selectively bind to methylated DNA control expression of viral and cellular genes, how cellular gene expression is selectively inhibited while viral gene expression is enhanced, and how viral DNA replication is regulated by cellular proteins. Recent studies focus on a new class of anti-viral agents that inhibit reactivation of Epstein-Barr virus from latency into lytic infection.
Education & Training
- Board CertificationAB of Internal Medicine, Internal Medicine (1972)
- Research FellowChildren's Hospital, Boston (1969)
- Research FellowHarvard Medical School (1969)
- ABHarvard College (1968)
- Intern & Assistant ResidentUniversity Hospital, Cleveland (1964)
- MDHarvard Medical School (1962)
Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Cancer Microbiology
- Epidemiology of Microbial Diseases
- Microbiology
- Molecular Biophysics and Biochemistry
- Molecular Virology
- Office of Cooperative Research
- Pediatrics
- Virology Laboratories
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale School of Public Health
- Yale University
- Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative