Heather Allore

Heather Allore

PhD
Professor; Director, Yale Program on Aging Biostatistics Core; Director, Data Management and Statistics Core, Yale Alzheimer's Disease Research Center; Co-director of the Biostatistics and Bioinformatics Core of the Yale Transdisciplinary Collaborative Center for Precision Medicine focused on Health Disparities; Adjunct Professor, Harldsplass Deaconess Hospital, University of Bergen, Norway

Contact Information

Heather Allore, PhD

Office Location

Mailing Address

  • Geriatrics

    300 George St Suite 775

    New Haven, CT, 06511

    United States

Heather Allore

Appointments

Biography

The focus of my research collaborations and methodological development work as Director of Biostatistics at the Yale Program on Aging. Innovative designs for multicomponent interventional trials and biostatistical methods are required to rigorously address the myriad of unanswered scientific questions related to geriatric health conditions. My research has focused on issues related to the design and analysis of studies of multiple chronic conditions using both clinical trials and observational studies, topics that are relevant to this application. With over 160 publications, I have served as a senior biostatistician on methods papers directly related to longitudinal methods, such as trajectories of functional disability, including the first published in New England Journal of Medicine. My applied research includes developing strategies for handling missing data that frequently occur in studies of older persons; I have compared different longitudinal imputation methods in the context of older persons where censoring due to death commonly occurs, which is a theme of the Biostatistical Core’s Development Project. In addition to my multicomponent and clustered trial design research, I have a wealth of experience conducting epidemiologic studies and is a recognized authority on longitudinal statistical methods, including extended Cox models for state transitions, generalized estimating equations, mixed effects models, latent class trajectory models, joint models and recently modified the average attributable fraction for a time-to-event outcome with time-varying medical conditions.I am the founder and leader of the field of Gerontological Biostatistics. This discipline trains biostatisticians for conducting collaborative clinical research with geriatricians and gerontologists and provides the basis for the development and extension of statistical methodology. Most recently, my group is exploring time-varying effects models that have never been used in aging research and this approach allows the effects of patient or clinical characteristics to varying over time. Dissemination of methods is through a user-friendly, web-based compendium (Gerontologic Research Algorithms and Statistical Programs or GRASP) that is facilitating an interchange of analytical strategies, programs and data structures for biostatisticians, epidemiologists, and other methodologists involved in gerontological research. These and other methodologic advances resulted in being an invited speaker at an NIH/NIA conference on Longitudinal Methods and another on Clinical Trial Design. In 2017, she co-chaired Study Design and Metrics of the NIH meeting on the 21st Century Cures Act: Inclusion Across the Lifespan. Other leadership roles I undertake include Director of the Yale Alzheimer's Disease Research Center's Data Management and Statistics Core and Co-director of the Biostatistics and Bioinformatics Core of the Yale Transdisciplinary Collaborative Center for Precision Medicine focused on Health Disparities, especially those with multiple chronic conditions. I have been a Steering Committee and Data and Measures Committee member of the AGING Initiative, which a collaboration of OAICs and the Healthcare Systems Research Network.  A defining hallmark of my biostatistical approach is that instead of developing analytic methods in the absence of a clinical question or adapting the study question to available analytical techniques, she adapts new statistical methods that suitably model the specific study question.

Education & Training

  • PhD
    Cornell University (1996)
  • MSc
    Cornell University (1993)
  • Postdoctoral Fellow
    Cornell University

Activities

  • Sabbatical
    Sydney, Australia; Bergen, Norway (2016-2017)
  • Vice President
    Guilford, United States (2009-2014)
    Guilford Land Conservation Trust

Honors & Recognition

AwardAwarding OrganizationDate
FellowGerontological Society of America2016
Women’s Midcareer Leadership Competitive ApplicationAmerican Association of Medical Colleges2014
Paul Harris FellowRotary International2012
NRI Competitive Grants Postdoctoral Fellowship 96-35204-3441NRI Competitive Grants Postdoctoral Fellowship1996
Gamma Sigma Delta Research AwardGamma Sigma Delta, Honor Society1991
HR Anslie Leadership AwardCornell University1990

Professional Service

OrganizationRoleDate
NIHSpecial Emphasis Panel Reviewer, Support of Competitive Research (SCORE)2015 - Present
Gerontological Society of AmericaHealth Sciences Membership Committee2014 - 2017
NIH/NIAPPG P01Alzheimer’s Disease2014 - Present
Data Safety Monitoring BoardElectroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) Study2014 - Present
NIH/NIAClinical Trial Advisory Panel2014 - Present
HMO Research Network/OAIC Aging InitiativeData and Measures Workgroup2014 - Present
NIH/NIASEP Review U19 DOMINANTLY INHERITED ALZHEIMER NETWORK2013
NIH/NIAIDSEP Reviewer, P01 Immunology, NIH/NIAID2011 - 2012
NIH/NIAIDSEP Immunology,2011 - 2012
Partnership for Anemia: Clinical and Translational TrialsData Safety Monitoring Board2010 - Present
Yale Center for Analytic ScienceYale Center for Analytic Science Executive Steering Committee2010 - Present
NIMHMember, Special Emphasis Panel, Treatment of Mental Illness2009 - 2010
Foundation for NIH review panel on SarcopeniaReview panel on Sarcopenia2009
Gerontological Society of AmericaConvener Gerontological Society of America Measures Statistics Research Design Section2008 - Present
CDCChair: CDC Special Emphasis Panel: Preparing People with Arthritis to Safely Select and Self Direct their Physical Activity2008 - Present
CDCCDC Mentored Public Health Research Scientist Development Award2007
NIH/NIANIH/NIA ASG Study Section2006 - 2012
Human Nutrition and Obesity Section USDA-NRICGPHuman Nutrition and Obesity Section USDA-NRICGP2006 - Present
USDA Small Business Initiative Grant ProgramUSDA Small Business Initiative Grant Program2003 - 2005
VA Cooperative Studies Program Coordinating CenterVA Cooperative Studies Program Coordinating Center Human Rights Committee2002 - Present

Departments & Organizations