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Soil-transmitted Helminth Infections


Four soil-transmitted helminths (STH) account for the majority of global STH infections - the roundworm (Ascaris lumbricoides), the whipworm (Trichuris trichiura) and the hookworms (Ancylostoma duodenale and Necator americanus). Globally, an estimated 820 million people are infected with Ascaris, 460 million with Trichuris and 440 million with hookworm. Dr. Debbie Humphries has been working with colleagues in Ghana to conduct field studies of hookworm infection in school children. Dr. Humphries’ work focuses on influences on exposure and susceptibility to hookworm infection, and influences on response to drug treatment. A combination of cross-sectional field studies, longitudinal studies, and qualitative field work is being used to characterize factors associated with susceptibility to hookworm infections, response to anthelminthic treatment, and susceptibility to reinfection.

Secondary faculty working on STH include Professor Michael Cappello. The Cappello lab focuses on studies of anthelminthic resistance and hookworm infection.

Secondary & Adjunct Faculty

  • Professor of Pediatrics (Infectious Disease), of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis; Chair, Council on African Studies, Whitney and Betty MacMillan Center for International and Area Studies; co-Director, Yale Africa Initiative

    Research Interests
    • Africa, Western
    • Developing Countries
    • Ghana
    • Hookworm Infections
    • Malaria
    • Microbiology
    • Pediatrics
    • Public Health
    • Tropical Medicine
    • Global Health
    • Infectious Disease Medicine

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