Globally, nationally and here in New Haven, the burden of poor health is borne unequally by marginalized, stigmatized and less powerful segments of the population. Social Behavioral Science researchers are working to narrow these gaps both through the development of interventions and through formative research that can help us to better understand the social production of health inequalities. Here in New Haven, we are working with residents of the city’s most disadvantaged neighborhoods in order to improve living conditions and health outcomes (Ickovics, Smith, Duffany). Beyond New Haven, we are also working to address social determinants of health disparities. Our research examines the effects of racism and stigma on health (Dovidio, Keene, Levy, Nunez-Smith, Pachankis, Wang), the ways that neighborhoods shape health (Keene, Ickovics, Ransome, Foster, Kershaw) and the role of housing as a social determinant of health (Keene). Globally we are working to ameliorate disparities in chronic diseases (Pérez-Escamilla), substance use (Ransome, Edelman, Foster) and sexual health (Miller, Kershaw, Ransome). Finally, through the Equity Research and Innovation Center (ERIC) we are developing evidence-based models to narrow health and healthcare inequalities, with a particular focus on racial and ethnic minority populations.