Nearly 1 in 4 people will experience a mental illness in their lifetimes. The sheer burden of mental illness on the global population demands effective and efficient public health approaches to assessment and intervention. Faculty, researchers, and students in the Social and Behavioral Sciences apply innovative, community-based methods to the prevention and treatment of mental illness across the life course. Using longitudinal and experimental methods, we seek to understand the interplay of mental health with substance use (White) and aging (Levy). We use psychophysiological approaches to examine the mental and physical health consequences of caregiving (Monin). Our interventions take advantage of emerging technologies, (Kershaw, Pachankis, Smith). We work with community-based organizations to uncover the influence of maternal depression on birth outcomes and parenting (Smith) and to implement community interventions for preventing substance use among adolescents and promoting resilience among trauma survivors (Tebes).