Rapid Data Sharing and Genomics Vital to China Virus Response
Virus genomics is playing a critical role in combating an emerging respiratory virus in China that has international health officials on alert. Yale School of Public Health scientist and genomics expert Nathan Grubaugh explains what's happening.
Yale Launches Comprehensive DNA Sequencing Project, With Aim of Predicting, Preventing, and Treating Gene-related Diseases
Generations, a collaboration between Yale School of Medicine and Yale New Haven Health System, is one of the largest DNA sequencing projects of its kind in the United States.
Yale study: Mapping tumors’ genes doesn’t improve survival
In this age of personalized medicine, sequencing the genes in a patient’s tumor can reveal mutations that may be treatable with targeted medications. But a new Yale School of Medicine-led study published Aug. 7 in the Journal of the American Medical Association shows that testing for many such mutations does not improve the chances of a patient’s survival. Data was analyzed from 5,688 patients with non-small cell lung cancer who were treated in a community cancer clinic rather than a large research institution. About 15 percent received broad-based sequencing of the tumor’s genome; the rest were tested only for two mutations, known as EGFR and ALK, for which medications are available. Incorporating variables into the analysis, the researchers found that mortality rates after 12 months were 41.1 percent for those who had the broad-based sequencing and 44.4 percent for those who just had the tests for EGFR and ALK.
Genetic Underpinnings of AMD, Other Diseases Revealed in YSPH Studies
A Yale School of Public Health researcher who discovered the gene behind age-related macular degeneration (AMD) has made new discoveries that increase the understanding of the mechanisms behind AMD and other diseases, including Parkinson’s disease.
In heavy drinkers, expression of gene predicts stress-induced alcohol consumption
Yale researchers have uncovered a set of genes that are expressed in stressed heavy drinkers that do not become activated in moderate drinkers. The new data, published in the journal Alcoholism: Clinical and Experimental Research, suggests a mechanism by which psychological stress triggers alcohol consumption in heavy drinkers.
Gene implicated in 'tanning dependence'
A team led by researchers at the Yale School of Public Health say they have found a gene associated with UV "tanning dependence", which has been characterized as a behavioral disorder. A study published Dec. 1 in Experimental Dermatology identified the gene through scanning the exomes of 79 people with symptoms of tanning dependency and 213 people who did not show dependency symptoms.
Breakthrough discovery opens new avenues for blocking transmission of African sleeping sickness
Scientists at the Yale School of Public Health and Yale School of Medicine have for the first time replicated in a laboratory setting the process of becoming infectious that occurs in the parasite that causes trypanosomiasis, more commonly known as African sleeping sickness.
The Genetics of Health - A School of Public Health researcher studies the human genome to find the origins of common diseases.
Andrew T. DeWan studies the human genome and how genetic abnormalities contribute to specific diseases. He is currently seeking to identify genes that are a factor in pregnancy-related complications such as preeclampsia and early childhood diseases such as asthma.
Skin cells reveal DNA’s genetic mosaic
The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body’s tissues, a finding with profound implications for genetic screening, according to Yale School of Medicine researchers.
Genome Sequencing Identifies Variants Possibly Linked to Childhood Asthma
The first comprehensive sequencing study of the protein coding regions of the genome in a family with both asthmatic and non-asthmatic members has identified several variants that may contribute to the potentially debilitating condition.
Genetic, Environmental Factors Identified in Social Networks
“Birds of a feather,” as the maxim goes, may “flock together,” but a new study by a Yale School of Public Health researcher suggests that a complex array of environmental and genetic factors influence which friendships and social networks people enter into.