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Supporting Data Management and Statistics

February 10, 2016
by Jill Max

The Yale Data Coordinating Core (YDCC) provides data management and statistical expertise to support multicenter studies. The core is a partnership among YCCI; the Yale Center for Analytical Sciences (YCAS); Emergency Medicine; the Yale Program on Aging (POA); and the Yale Center for Medical Informatics (YCMI). It comprises faculty from the School of Medicine and School of Public Health with decades of expertise in biostatistics, epidemiology, clinical trials, and informatics, along with a highly trained technical staff skilled in systems programming, data management, data analysis, and statistical programming. Headed by YCAS director Peter Peduzzi, PhD, its faculty members include YCAS deputy director James Dziura, MPH, PhD; Peter Charpentier, associate director for data management; Heather Allore, PhD, director of the Yale Program on Aging biostatistics core; Cynthia Brandt, MD, MPH; and Charles Lu, associate director for technology and system development/bioinformatics.

The center works with the Program on Aging, the Alzheimer’s Disease Research Center, Yale Cancer Center, and other programs to support such projects as:

• The Autism Biomarkers Consortium for Clinical Trials (ABC-CT), a multicenter study to develop objective measurements of social functioning and communication in children with autism, for which it is the Data Coordinating Core.

• Guanfacine for the Treatment of Hyperactivity in Pervasive Development Disorder, a multicenter trial that involves managing regulatory matters, data management, and biostatistical services.

Integrated Stepped Care for Unhealthy Alcohol Use in HIV, a multicenter trial that involves data management services, preparation of Data and Safety Monitoring Board (DSMB) reports, and statistical analysis.

• Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE), a multicenter trial that involves data management services, DSMB reports, and statistical analysis.

“We recognized that supporting large multicenter trials requires high-quality analytics and data cores,” said YCCI Director Robert Sherwin, MD. “We’re excited to be able to bring these resources together to support this work, which can benefit so many patients.”

Submitted by Lisa Brophy on February 05, 2016