Perinatal Studies
Neurodevelopmental Effects of Perfluorinated Chemicals (PFCs)
Perfluorinated chemicals (PFCs) are widespread man-made persistent organic pollutants with endocrine disruptive and neurotoxic activities observed in animals. Almost all pregnant women and children in Denmark and the US were found to be involuntarily and nearly ubiquitously exposed to these synthetic compounds, but human studies that evaluate neurodevelopmental effects of PFCs are sparse. We will use data from the Danish National Birth Cohort (DNBC) to study the impact of prenatal exposure to PFCs on a broad range of critical neurodevelopmental endpoints spanning from ages 5 to 16. Our study findings will advance scientific insights into the biologic mechanisms of developmental brain disorders and may influence regulation of these chemical contaminants globally.
Principal Investigator:
- Zeyan Liew, PhD, MPH, Assistant Professor, Department of Environmental Health Sciences; email: zeyan.liew@yale.edu
Paternal and Maternal Perfluoroalkyl Substance Exposure and Offspring Health
- Zeyan Liew, PhD, MPH, Assistant Professor, Department of Environmental Health Sciences; email: zeyan.liew@yale.edu
The Effect of Phenol Exposure
The effect of phenol exposure on reproductive function and the urinary metabolome
Phenols are endocrine-disrupting chemicals found in many everyday items, ranging from personal care products to food packaging materials. This study investigates whether exposure to common levels of phenols impacts reproductive function and fertility among women and the mechanisms behind possible associations. Results from this study could be used to help guide future public health recommendations about safe exposure levels, and how best to minimize exposures.
Contact PI/Graduate Student (PhD Candidate):
Primary Sponsor:
- Caroline Johnson, PhD, Associate Professor, Department of Environmental Health Sciences; email: caroline.johnson@yale.edu