COVID-NET

The Yale EIP RESP-NET team is conducting population-based surveillance for laboratory-confirmed COVID-19 associated hospitalizations in southern Connecticut. Yale EIP is one of 13 sites conducting COVID-NET surveillance across the country. Weekly hospitalization rates from COVID-NET are available on CDC’s website.

Summary

In March 2020, in response to the outbreak of novel Coronavirus 2019 disease, EIPs launched COVID-NET. Leveraging the FluSurv-NET and RSV-NET surveillance platforms already in existence, participating COVID-NET sites conduct SARS-CoV-2 surveillance to investigate the characteristics and burden of children and adults hospitalized with SARS-CoV-2.

Goals & Objectives

Primary:

Estimate overall and age-specific COVID-19-associated hospitalization rates in a timely manner (e.g., daily and/or weekly).
Estimate overall and age-specific COVID-19-associated ICU admission rates and in-hospital mortality rates in all ages.

Secondary:

Describe the characteristics, clinical features, and clinical course (e.g., severe illness and SARS-CoV-2-associated complications) of persons hospitalized with SARS-CoV-2 infection.
Describe laboratory-confirmed COVID-19 and RSV hospitalizations by COVID-19 vaccination status among patients eligible to be vaccinated.
Describe maternal COVID-19 vaccination status among children up to 2 years old hospitalized with COVID-19.
Assess risk factors for COVID-19-associated complications among hospitalized cases.
Utilize hospitalization data and other clinical data sources to estimate the national disease burden of COVID-19.

Project Contact:

Kimberly Yousey-Hindes, MPH, CPH
Program Manager, RESP-NET
Kimberly.yousey-hindes@yale.edu

Staff:

Daewi Kim
Emily Zmek
Hazhia Sorosindi
Julia Desiato
Julie Plano
Noelle Labozzo
Melanie Szahaj

Recent COVID-NET Publications

2023

Association of Chronic Medical Conditions With Severe Outcomes Among Nonpregnant Adults 18-49 Years Old Hospitalized With Influenza, FluSurv-NET, 2011-2019.Famati EA, Ujamaa D, O'Halloran A, Kirley PD, Chai SJ, Armistead I, Alden NB, Yousey-Hindes K, Openo KP, Ryan PA, Monroe ML, Falkowski A, Kim S, Lynfield R, McMahon M, Angeles KM, Khanlian SA, Spina NL, Bennett NM, Gaitán MA, Shiltz E, Lung K, Thomas A, Talbot HK, Schaffner W, George A, Staten H, Bozio CH, Garg S. Open Forum Infect Dis. 2023 Dec; 2023 Nov 29. PMID: 38130595.
COVID-19-Associated Hospitalizations Among U.S. Adults Aged ≥65 Years - COVID-NET, 13 States, January-August 2023.Taylor CA, Patel K, Patton ME, Reingold A, Kawasaki B, Meek J, Openo K, Ryan PA, Falkowski A, Bye E, Plymesser K, Spina N, Tesini BL, Moran NE, Sutton M, Talbot HK, George A, Havers FP. MMWR Morb Mortal Wkly Rep. 2023 Oct 6; 2023 Oct 6. PMID: 37796744.
Vaccination Status and Trends in Adult Coronavirus Disease 2019-Associated Hospitalizations by Race and Ethnicity: March 2020-August 2022.Ko JY, Pham H, Anglin O, Chai SJ, Alden NB, Meek J, Anderson EJ, Weigel A, Kohrman A, Lynfield R, Rudin D, Barney G, Bennett NM, Billing LM, Sutton M, Talbot HK, Swain A, Havers FP, Taylor CA. Clin Infect Dis. 2023 Sep 18. PMID: 37132204.
Bacterial and viral infections among adults hospitalized with COVID-19, COVID-NET, 14 states, March 2020-April 2022.Shah MM, Patel K, Milucky J, Taylor CA, Reingold A, Armistead I, Meek J, Anderson EJ, Weigel A, Reeg L, Como-Sabetti K, Ropp SL, Muse A, Bushey S, Shiltz E, Sutton M, Talbot HK, Chatelain R, Havers FP. Influenza Other Respir Viruses. 2023 Mar; 2023 Mar 2. PMID: 36875205.
Comparison of Influenza and Coronavirus Disease 2019-Associated Hospitalizations Among Children Younger Than 18 Years Old in the United States: FluSurv-NET (October-April 2017-2021) and COVID-NET (October 2020-September 2021).Delahoy MJ, Ujamaa D, Taylor CA, Cummings C, Anglin O, Holstein R, Milucky J, O'Halloran A, Patel K, Pham H, Whitaker M, Reingold A, Chai SJ, Alden NB, Kawasaki B, Meek J, Yousey-Hindes K, Anderson EJ, Openo KP, Weigel A, Teno K, Reeg L, Leegwater L, Lynfield R, McMahon M, Ropp S, Rudin D, Muse A, Spina N, Bennett NM, Popham K, Billing LM, Shiltz E, Sutton M, Thomas A, Schaffner W, Talbot HK, Crossland MT, McCaffrey K, Hall AJ, Burns E, McMorrow M, Reed C, Havers FP, Garg S. Clin Infect Dis. 2023 Feb 8. PMID: 35594564.
Codetections of Other Respiratory Viruses Among Children Hospitalized With COVID-19.Agathis NT, Patel K, Milucky J, Taylor CA, Whitaker M, Pham H, Anglin O, Chai SJ, Alden NB, Meek J, Anderson EJ, Weigel A, Kim S, Lynfield R, Smelser C, Muse A, Popham K, Billing LM, Sutton M, Talbot HK, George A, McMorrow M, Havers FP. Pediatrics. 2023 Feb 1. PMID: 36995184.

2022

COVID-19-Associated Hospitalizations Among U.S. Infants Aged <6 Months - COVID-NET, 13 States, June 2021-August 2022.Hamid S, Woodworth K, Pham H, Milucky J, Chai SJ, Kawasaki B, Yousey-Hindes K, Anderson EJ, Henderson J, Lynfield R, Pacheco F, Barney G, Bennett NM, Shiltz E, Sutton M, Talbot HK, Price A, Havers FP, Taylor CA. MMWR Morb Mortal Wkly Rep. 2022 Nov 11; 2022 Nov 11. PMID: 36355608.
Characteristics and treatment of hospitalized pregnant women with COVID-19.Sekkarie A, Woodruff R, Whitaker M, Kramer MR, Zapata LB, Ellington SR, Meaney-Delman DM, Pham H, Patel K, Taylor CA, Chai SJ, Kawasaki B, Meek J, Openo KP, Weigel A, Leegwater L, Como-Sabetti K, Ropp SL, Muse A, Bennett NM, Billing LM, Sutton M, Talbot HK, Hill M, Havers FP. Am J Obstet Gynecol MFM. 2022 Nov; 2022 Aug 12. PMID: 35970493.
Laboratory-Confirmed COVID-19-Associated Hospitalizations Among Adults During SARS-CoV-2 Omicron BA.2 Variant Predominance - COVID-19-Associated Hospitalization Surveillance Network, 14 States, June 20, 2021-May 31, 2022.Havers FP, Patel K, Whitaker M, Milucky J, Reingold A, Armistead I, Meek J, Anderson EJ, Weigel A, Reeg L, Seys S, Ropp SL, Spina N, Felsen CB, Moran NE, Sutton M, Talbot HK, George A, Taylor CA. MMWR Morb Mortal Wkly Rep. 2022 Aug 26; 2022 Aug 26. PMID: 36006841.
Factors Associated with Severe Outcomes Among Immunocompromised Adults Hospitalized for COVID-19 - COVID-NET, 10 States, March 2020-February 2022.Singson JRC, Kirley PD, Pham H, Rothrock G, Armistead I, Meek J, Anderson EJ, Reeg L, Lynfield R, Ropp S, Muse A, Felsen CB, Sutton M, Talbot HK, Havers FP, Taylor CA, Reingold A, Chai SJ. MMWR Morb Mortal Wkly Rep. 2022 Jul 8; 2022 Jul 8. PMID: 35797216.
Hospitalizations of Children Aged 5-11 Years with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 2020-February 2022.Shi DS, Whitaker M, Marks KJ, Anglin O, Milucky J, Patel K, Pham H, Chai SJ, Kawasaki B, Meek J, Anderson EJ, Weigel A, Henderson J, Lynfield R, Ropp SL, Muse A, Bushey S, Billing LM, Sutton M, Talbot HK, Price A, Taylor CA, Havers FP. MMWR Morb Mortal Wkly Rep. 2022 Apr 22; 2022 Apr 22. PMID: 35446827.
COVID-19-Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status - COVID-NET, 14 States, July 2021-January 2022.Taylor CA, Whitaker M, Anglin O, Milucky J, Patel K, Pham H, Chai SJ, Alden NB, Yousey-Hindes K, Anderson EJ, Teno K, Reeg L, Como-Sabetti K, Bleecker M, Barney G, Bennett NM, Billing LM, Sutton M, Talbot HK, McCaffrey K, Havers FP. MMWR Morb Mortal Wkly Rep. 2022 Mar 25; 2022 Mar 25. PMID: 35324880.
Hospitalization of Infants and Children Aged 0-4 Years with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 2020-February 2022.Marks KJ, Whitaker M, Agathis NT, Anglin O, Milucky J, Patel K, Pham H, Kirley PD, Kawasaki B, Meek J, Anderson EJ, Weigel A, Kim S, Lynfield R, Ropp SL, Spina NL, Bennett NM, Shiltz E, Sutton M, Talbot HK, Price A, Taylor CA, Havers FP. MMWR Morb Mortal Wkly Rep. 2022 Mar 18; 2022 Mar 18. PMID: 35298458.
Hospitalizations of Children and Adolescents with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, July 2021-January 2022.Marks KJ, Whitaker M, Anglin O, Milucky J, Patel K, Pham H, Chai SJ, Kirley PD, Armistead I, McLafferty S, Meek J, Yousey-Hindes K, Anderson EJ, Openo KP, Weigel A, Henderson J, Nunez VT, Como-Sabetti K, Lynfield R, Ropp SL, Smelser C, Barney GR, Muse A, Bennett NM, Bushey S, Billing LM, Shiltz E, Abdullah N, Sutton M, Schaffner W, Talbot HK, Chatelain R, George A, Taylor CA, McMorrow ML, Perrine CG, Havers FP. MMWR Morb Mortal Wkly Rep. 2022 Feb 18; 2022 Feb 18. PMID: 35176003.

2021

Severity of Disease Among Adults Hospitalized with Laboratory-Confirmed COVID-19 Before and During the Period of SARS-CoV-2 B.1.617.2 (Delta) Predominance - COVID-NET, 14 States, January-August 2021.Taylor CA, Patel K, Pham H, Whitaker M, Anglin O, Kambhampati AK, Milucky J, Chai SJ, Kirley PD, Alden NB, Armistead I, Meek J, Yousey-Hindes K, Anderson EJ, Openo KP, Teno K, Weigel A, Monroe ML, Ryan PA, Henderson J, Nunez VT, Bye E, Lynfield R, Poblete M, Smelser C, Barney GR, Spina NL, Bennett NM, Popham K, Billing LM, Shiltz E, Abdullah N, Sutton M, Schaffner W, Talbot HK, Ortega J, Price A, Garg S, Havers FP. MMWR Morb Mortal Wkly Rep. 2021 Oct 29; 2021 Oct 29. PMID: 34710076.
Clinical Trends Among U.S. Adults Hospitalized With COVID-19, March to December 2020 : A Cross-Sectional Study.Garg S, Patel K, Pham H, Whitaker M, O'Halloran A, Milucky J, Anglin O, Kirley PD, Reingold A, Kawasaki B, Herlihy R, Yousey-Hindes K, Maslar A, Anderson EJ, Openo KP, Weigel A, Teno K, Ryan PA, Monroe ML, Reeg L, Kim S, Como-Sabetti K, Bye E, Shrum Davis S, Eisenberg N, Muse A, Barney G, Bennett NM, Felsen CB, Billing L, Shiltz J, Sutton M, Abdullah N, Talbot HK, Schaffner W, Hill M, Chatelain R, Wortham J, Taylor C, Hall A, Fry AM, Kim L, Havers FP. Ann Intern Med. 2021 Oct; 2021 Aug 10. PMID: 34370517.
Census tract socioeconomic indicators and COVID-19-associated hospitalization rates-COVID-NET surveillance areas in 14 states, March 1-April 30, 2020.Wortham JM, Meador SA, Hadler JL, Yousey-Hindes K, See I, Whitaker M, O'Halloran A, Milucky J, Chai SJ, Reingold A, Alden NB, Kawasaki B, Anderson EJ, Openo KP, Weigel A, Monroe ML, Ryan PA, Kim S, Reeg L, Lynfield R, McMahon M, Sosin DM, Eisenberg N, Rowe A, Barney G, Bennett NM, Bushey S, Billing LM, Shiltz J, Sutton M, West N, Talbot HK, Schaffner W, McCaffrey K, Spencer M, Kambhampati AK, Anglin O, Piasecki AM, Holstein R, Hall AJ, Fry AM, Garg S, Kim L. PLoS One. 2021; 2021 Sep 24. PMID: 34559838.
Hospitalizations Associated with COVID-19 Among Children and Adolescents - COVID-NET, 14 States, March 1, 2020-August 14, 2021.Delahoy MJ, Ujamaa D, Whitaker M, O'Halloran A, Anglin O, Burns E, Cummings C, Holstein R, Kambhampati AK, Milucky J, Patel K, Pham H, Taylor CA, Chai SJ, Reingold A, Alden NB, Kawasaki B, Meek J, Yousey-Hindes K, Anderson EJ, Openo KP, Teno K, Weigel A, Kim S, Leegwater L, Bye E, Como-Sabetti K, Ropp S, Rudin D, Muse A, Spina N, Bennett NM, Popham K, Billing LM, Shiltz E, Sutton M, Thomas A, Schaffner W, Talbot HK, Crossland MT, McCaffrey K, Hall AJ, Fry AM, McMorrow M, Reed C, Garg S, Havers FP. MMWR Morb Mortal Wkly Rep. 2021 Sep 10; 2021 Sep 10. PMID: 34499627.
Effectiveness of COVID-19 Vaccines in Preventing Hospitalization Among Adults Aged ≥65 Years - COVID-NET, 13 States, February-April 2021.Moline HL, Whitaker M, Deng L, Rhodes JC, Milucky J, Pham H, Patel K, Anglin O, Reingold A, Chai SJ, Alden NB, Kawasaki B, Meek J, Yousey-Hindes K, Anderson EJ, Farley MM, Ryan PA, Kim S, Nunez VT, Como-Sabetti K, Lynfield R, Sosin DM, McMullen C, Muse A, Barney G, Bennett NM, Bushey S, Shiltz J, Sutton M, Abdullah N, Talbot HK, Schaffner W, Chatelain R, Ortega J, Murthy BP, Zell E, Schrag SJ, Taylor C, Shang N, Verani JR, Havers FP. MMWR Morb Mortal Wkly Rep. 2021 Aug 13; 2021 Aug 13. PMID: 34383730.
Hospitalization of Adolescents Aged 12-17 Years with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 1, 2020-April 24, 2021.Havers FP, Whitaker M, Self JL, Chai SJ, Kirley PD, Alden NB, Kawasaki B, Meek J, Yousey-Hindes K, Anderson EJ, Openo KP, Weigel A, Teno K, Monroe ML, Ryan PA, Reeg L, Kohrman A, Lynfield R, Como-Sabetti K, Poblete M, McMullen C, Muse A, Spina N, Bennett NM, Gaitán M, Billing LM, Shiltz J, Sutton M, Abdullah N, Schaffner W, Talbot HK, Crossland M, George A, Patel K, Pham H, Milucky J, Anglin O, Ujamaa D, Hall AJ, Garg S, Taylor CA. MMWR Morb Mortal Wkly Rep. 2021 Jun 11; 2021 Jun 11. PMID: 34111061.
Risk Factors for Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization: COVID-19-Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System.Ko JY, Danielson ML, Town M, Derado G, Greenlund KJ, Kirley PD, Alden NB, Yousey-Hindes K, Anderson EJ, Ryan PA, Kim S, Lynfield R, Torres SM, Barney GR, Bennett NM, Sutton M, Talbot HK, Hill M, Hall AJ, Fry AM, Garg S, Kim L. Clin Infect Dis. 2021 Jun 1. PMID: 32945846.
Risk Factors for Intensive Care Unit Admission and In-hospital Mortality Among Hospitalized Adults Identified through the US Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET).Kim L, Garg S, O'Halloran A, Whitaker M, Pham H, Anderson EJ, Armistead I, Bennett NM, Billing L, Como-Sabetti K, Hill M, Kim S, Monroe ML, Muse A, Reingold AL, Schaffner W, Sutton M, Talbot HK, Torres SM, Yousey-Hindes K, Holstein R, Cummings C, Brammer L, Hall AJ, Fry AM, Langley GE. Clin Infect Dis. 2021 May 4. PMID: 32674114.
Characteristics of Adults Aged 18-49 Years Without Underlying Conditions Hospitalized With Laboratory-Confirmed Coronavirus Disease 2019 in the United States: COVID-NET-March-August 2020.Owusu D, Kim L, O'Halloran A, Whitaker M, Piasecki AM, Reingold A, Alden NB, Maslar A, Anderson EJ, Ryan PA, Kim S, Como-Sabetti K, Hancock EB, Muse A, Bennett NM, Billing LM, Sutton M, Talbot HK, Ortega J, Brammer L, Fry AM, Hall AJ, Garg S. Clin Infect Dis. 2021 Mar 1. PMID: 33270136.

2020

COVID-19 Investigational Treatments in Use Among Hospitalized Patients Identified Through the US Coronavirus Disease 2019-Associated Hospitalization Surveillance Network, March 1-June 30, 2020.Acosta AM, Mathis AL, Budnitz DS, Geller AI, Chai SJ, Alden NB, Meek J, Anderson EJ, Ryan P, Kim S, Como-Sabetti K, Torres S, Dufort E, Bennett NM, Billing LM, Sutton M, Keipp Talbot H, George A, Pham H, Hall AJ, Fry A, Garg S, Kim L. Open Forum Infect Dis. 2020 Nov; 2020 Nov 9. PMID: 33274249.
COVID-19-Associated Hospitalizations Among Health Care Personnel - COVID-NET, 13 States, March 1-May 31, 2020.Kambhampati AK, O'Halloran AC, Whitaker M, Magill SS, Chea N, Chai SJ, Daily Kirley P, Herlihy RK, Kawasaki B, Meek J, Yousey-Hindes K, Anderson EJ, Openo KP, Monroe ML, Ryan PA, Kim S, Reeg L, Como-Sabetti K, Danila R, Davis SS, Torres S, Barney G, Spina NL, Bennett NM, Felsen CB, Billing LM, Shiltz J, Sutton M, West N, Schaffner W, Talbot HK, Chatelain R, Hill M, Brammer L, Fry AM, Hall AJ, Wortham JM, Garg S, Kim L. MMWR Morb Mortal Wkly Rep. 2020 Oct 30; 2020 Oct 30. PMID: 33119554.
Characteristics and Maternal and Birth Outcomes of Hospitalized Pregnant Women with Laboratory-Confirmed COVID-19 - COVID-NET, 13 States, March 1-August 22, 2020.Delahoy MJ, Whitaker M, O'Halloran A, Chai SJ, Kirley PD, Alden N, Kawasaki B, Meek J, Yousey-Hindes K, Anderson EJ, Openo KP, Monroe ML, Ryan PA, Fox K, Kim S, Lynfield R, Siebman S, Davis SS, Sosin DM, Barney G, Muse A, Bennett NM, Felsen CB, Billing LM, Shiltz J, Sutton M, West N, Schaffner W, Talbot HK, George A, Spencer M, Ellington S, Galang RR, Gilboa SM, Tong VT, Piasecki A, Brammer L, Fry AM, Hall AJ, Wortham JM, Kim L, Garg S. MMWR Morb Mortal Wkly Rep. 2020 Sep 25; 2020 Sep 25. PMID: 32970655.
Hospitalization Rates and Characteristics of Children Aged <18 Years Hospitalized with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 1-July 25, 2020.Kim L, Whitaker M, O'Halloran A, Kambhampati A, Chai SJ, Reingold A, Armistead I, Kawasaki B, Meek J, Yousey-Hindes K, Anderson EJ, Openo KP, Weigel A, Ryan P, Monroe ML, Fox K, Kim S, Lynfield R, Bye E, Shrum Davis S, Smelser C, Barney G, Spina NL, Bennett NM, Felsen CB, Billing LM, Shiltz J, Sutton M, West N, Talbot HK, Schaffner W, Risk I, Price A, Brammer L, Fry AM, Hall AJ, Langley GE, Garg S. MMWR Morb Mortal Wkly Rep. 2020 Aug 14; 2020 Aug 14. PMID: 32790664.
Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 - COVID-NET, 14 States, March 1-30, 2020.Garg S, Kim L, Whitaker M, O'Halloran A, Cummings C, Holstein R, Prill M, Chai SJ, Kirley PD, Alden NB, Kawasaki B, Yousey-Hindes K, Niccolai L, Anderson EJ, Openo KP, Weigel A, Monroe ML, Ryan P, Henderson J, Kim S, Como-Sabetti K, Lynfield R, Sosin D, Torres S, Muse A, Bennett NM, Billing L, Sutton M, West N, Schaffner W, Talbot HK, Aquino C, George A, Budd A, Brammer L, Langley G, Hall AJ, Fry A. MMWR Morb Mortal Wkly Rep. 2020 Apr 17; 2020 Apr 17. PMID: 32298251.