Babesia; Babesiosis; Borrelia; Chikungunya virus; Climate; Epidemiology; Biological Evolution; Insect Vectors; Lyme Disease; Parasitology; Public Health; Ticks; Global Health; Evolution, Planetary; Climate Change
Public Health Interests
Lyme Disease; Parasitology; Tropical Diseases; Viruses
Professor Fish’s area of research interest is the ecology of vector-borne pathogens. Recent emphasis has been on tick-borne pathogens causing Lyme disease, human anaplasmosis and babesiosis, and on mosquito-borne West Nile virus and dengue fever. Current projects include experimental manipulation of natural transmission cycles, vaccination of wildlife reservoirs against vectors and vector-borne pathogens, interactions among multiple pathogens in vectors and hosts, vector competence for viral and bacterial pathogens, and pathogen population genetics. Spatial analysis of pathogen prevalence using satellite imagery and geographic information systems forms the basis for applied studies in landscape epidemiology. His laboratory maintains colonies of ticks and mosquitoes for experimental studies, and a network of field sites is available for ecological studies. Prof. Fish is Director of the Yale Center for EcoEpidemiology, an interdisciplinary center that seeks to integrate environmental science and ecology with medical epidemiology. He is also on the Steering Committee of the Yale Climate and Energy Institute where he coordinates campus wide research on climate and human health.
Specialized Terms: Vector-borne diseases; ecology; evolution; epidemiology; prevention; climate change; borrelia; babesia; ticks; mosquitoes
Extensive Research Description
Professor Fish's research interests are in the areas of ecology and prevention of vector-borne infectious diseases. Recent emphasis has been on tick-borne pathogens causing Lyme disease and human ehrlichiosis in the northeastern U.S. Current projects include natural and artificial regulation of vector populations, vector competence for viral and bacterial pathogens, co-infection and transmissions of multiple pathogens, geographic and spatial analysis of epidemiological data, and the use of satellite imagery to predict vector-borne disease risk.
- Alfaro-Murillo JA, Parpia AS, Fitzpatrick MC, Tamagnan JA, Medlock J, Ndeffo-Mbah ML, Fish D, Avila-Aguero ML, Marin R, Ko AI, Galvani AP. A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. PLoS Negl Trop Dis. 2016;10(5):e0004743. Epub 2016/05/21. doi: 10.1371/journal.pntd.0004743. PubMed PMID: 27205899; PMCID: PMC4874682.
- Ndeffo-Mbah ML, Durham DP, Skrip LA, Nsoesie EO, Brownstein JS, Fish D, Galvani AP. Evaluating the effectiveness of localized control strategies to curtail chikungunya. Sci Rep. 2016;6:23997. Epub 2016/04/06. doi: 10.1038/srep23997. PubMed PMID: 27045523; PMCID: PMC4820747.
- Krause PJ, Fish D, Narasimhan S, Barbour AG. Borrelia miyamotoi infection in nature and in humans. Clin Microbiol Infect. 2015;21(7):631-9. Epub 2015/02/24. doi: 10.1016/j.cmi.2015.02.006. PubMed PMID: 25700888; PMCID: PMC4470780.
- Diuk-Wasser MA, Liu Y, Steeves TK, Folsom-O'Keefe C, Dardick KR, Lepore T, Bent SJ, Usmani-Brown S, Telford SR, 3rd, Fish D, Krause PJ. Monitoring human babesiosis emergence through vector surveillance New England, USA. Emerg Infect Dis. 2014;20(2):225-31. Epub 2014/01/23. doi: 10.3201/eid1302/130644. PubMed PMID: 24447577; PMCID: PMC3901474.
- Diuk-Wasser MA, Hoen AG, Cislo P, Brinkerhoff R, Hamer SA, Rowland M, et al. (2012) Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States. Am J Trop Med Hyg. 86(2): 320-7.
- Hoen AG, Margos G, Bent SJ, Diuk-Wasser MA, Barbour A, Kurtenbach K, Fish D. Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events. Proc Natl Acad Sci U S A. 2009;106(35):15013-8. Epub 2009/08/27. doi: 10.1073/pnas.0903810106. PubMed PMID: 19706476; PMCID: PMC2727481.
- 2. Brown HE, Childs JE, Diuk-Wasser MA, Fish D. Ecological factors associated with West Nile virus transmission, northeastern United States. Emerg Infect Dis. 2008;14(10):1539-45. Epub 2008/10/02. doi: 10.3201/eid1410.071396. PubMed PMID: 18826816; PMCID: PMC2609885.
- Nsoesie EO, Ricketts RP, Brown HE, Fish D, Durham DP, Ndeffo Mbah ML, Christian T, Ahmed S, Marcellin C, Shelly E, Owers K, Wenzel N, Galvani AP, Brownstein JS. Spatial and Temporal Clustering of Chikungunya Virus Transmission in Dominica. PLoS Negl Trop Dis. 2015;9(8):e0003977. Epub 2015/08/15. doi: 10.1371/journal.pntd.0003977. PubMed PMID: 26274813; PMCID: PMC4537218.